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Bioinformatics. 2007 Oct 1;23(19):2619-21. Epub 2007 Jun 5.

dPattern: transcription factor binding site (TFBS) discovery in human genome using a discriminative pattern analysis.

Author information

1
Department of Computer Science, Indiana University - Bloomington, IN 47404, USA.

Abstract

MOTIVATION:

Transcription factor binding sites (TFBSs) are typically short in length, thus search with a profile model from known TFBSs produces many false positives. When combined with additional information, gene expression data in this article, sensitivity and specificity of TFBS search can be improved significantly.

RESULTS:

By modifying our previous REFINEMENT approach, we developed dPattern that searches for occurrences of TFBSs in the promotor regions of up/down regulated or random genes.

PMID:
17550915
DOI:
10.1093/bioinformatics/btm288
[Indexed for MEDLINE]

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