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Architecture of a microRNA-controlled gene regulatory network that diversifies neuronal cell fates.

Author information

1
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA.

Abstract

Individual cell types are defined by the expression of specific gene batteries. Regulatory networks that control cell-type-specific gene expression programs in the nervous system are only beginning to be understood. This paper summarizes a complex gene regulatory network, composed of several transcription factors and microRNAs (miRNAs), that controls neuronal subclass specification in the nervous system of the nematode Caenorhabditis elegans.

PMID:
17381295
DOI:
10.1101/sqb.2006.71.006
[Indexed for MEDLINE]

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