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Neurosci Lett. 2007 Mar 30;415(3):237-41. Epub 2007 Feb 14.

Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia.

Author information

1
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.

Abstract

The present study was undertaken to determine if the neuroprotective effect of 17beta-estradiol (E(2)) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E(2) at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E(2) extended the therapeutic window to 6h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.

PMID:
17331646
PMCID:
PMC1936945
DOI:
10.1016/j.neulet.2007.01.074
[Indexed for MEDLINE]
Free PMC Article

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