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Fertil Steril. 2007 Sep;88(3):724-6. Epub 2007 Feb 28.

Letrozole and norethisterone acetate in rectovaginal endometriosis.

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Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, Genoa, Italy.


This open-label prospective study evaluated the efficacy of letrozole (2.5 mg/day) combined with norethisterone acetate (2.5 mg/day) in the treatment of pain symptoms related to the presence of rectovaginal endometriosis. The treatment significantly and quickly decreased the intensity of symptoms, but pain recurred at 3-month follow-up; five women underwent surgery during the follow-up, and histologic examination of rectovaginal nodules revealed the presence of active endometriotic lesions.

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