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J Struct Biol. 2007 May;158(2):188-95. Epub 2006 Dec 27.

Density-based score for selecting near-native atomic models of unknown structures.

Author information

1
The Burnham Institute for Medical Research, Bioinformatics and Systems Biology Program, La Jolla, CA 92037, USA.

Abstract

We present a low-resolution density-based scoring scheme for selecting high-quality models from a large pool of lesser quality models. We use pre-configured decoy data sets that contain large numbers of models with different degrees of correctness to evaluate the performance of the strategy. We find that the scoring scheme consistently identifies one of the highest quality models for a wide variety of target structures, resolution ranges, and noise models. Tests with experimental data yield similar results.

PMID:
17296314
PMCID:
PMC2175034
DOI:
10.1016/j.jsb.2006.12.005
[Indexed for MEDLINE]
Free PMC Article

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