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J Cosmet Dermatol. 2002 Oct;1(3):120-3.

Facial lipoatrophy: report of five cases after injection of synthetic filler into naso-labial folds.

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Service of Dermatology, Hôpital Henri Mondor, 94100 Créteil, France.



Facial lipoatrophies are rare disfiguring syndromes, most commonly characterized by loss of buccal fat pads.


To demonstrate a relationship between facial lipoatrophy and a new synthetic filler device (Profill) used to correct naso-labial folds.


Five cases of lipoatrophy, appeared 9 months or later after Profill injections. No systematic abnormalities were found. In one case biopsy reported a destruction of adipocytes with intense fibrosis in the hypodermis.


The culpability of this new biodegradable product is highlighted. To our knowledge, this is the first time this adverse reaction has been reported.


Serious adverse reactions may appear months after Profill injection, skin testing is not always predictive or sufficient. Clinical studies with long-term follow-up need to be carried out before new filler devices are launched on the market.

[Indexed for MEDLINE]

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