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Biol Psychiatry. 2007 Feb 1;61(3):279-84. Epub 2006 Nov 27.

Relationship of movements and behaviors to Group A Streptococcus infections in elementary school children.

Author information

1
Department of Psychiatry, College of Medicine, Gainesville, Florida 32610, USA. tmurphy@psychiatry.ufl.edu

Abstract

BACKGROUND:

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) research is based on the hypothesis that infections trigger changes in behavior and movement in children.

METHODS:

We enrolled 693 children (ages 3 to 12 years) into a systematic, longitudinal study. Data were collected monthly for 8 months (October-May) to determine point prevalence of Group A Streptococcal (GAS) infections, tics, behavior, and choreiform movements. Simultaneous throat cultures were obtained, and relational analyses were made between GAS and movement/observation ratings.

RESULTS:

Combined behavior/GAS associations (concurrent with or 3 subsequent months to GAS) revealed a strong relationship, relative risk (RR) of 1.71 (p < .0001). Detailed analysis revealed that balance/swaying and non-tic grimacing were responsible for a significant proportion of this association (RR = 2.92, p < .0001). A strong seasonal pattern was found, with fall being more significant for GAS infections and observation ratings (p < .0001) compared with winter/spring. Children with repeated streptococcus (n = 64) showed higher rates of behavior and distal choreiform observations (p = .005).

CONCLUSIONS:

Motor/behavior changes were noted to occur in relationship to positive GAS culture with support that repeated GAS increases risk.

PMID:
17126304
DOI:
10.1016/j.biopsych.2006.08.031
[Indexed for MEDLINE]

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