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Nat Rev Immunol. 2006 Dec;6(12):883-94. Epub 2006 Nov 17.

Structural determinants of T-cell receptor bias in immunity.

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Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.


Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors (TCRs) that are selected from a diverse, naive repertoire. Here, we review the evidence for these TCR biases, focusing on crystallographic analysis of the structural constraints that determine the binding of a TCR to its ligand and the persistence of certain TCRs in an immune repertoire. We discuss the ways in which diversity in a selected TCR repertoire can contribute to protective immunity and the implications of this for vaccine design and immunotherapy.

[Indexed for MEDLINE]

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