Send to

Choose Destination
Behav Genet. 2007 Jan;37(1):51-60. Epub 2006 Sep 19.

Endophenotype approach to developmental psychopathology: implications for autism research.

Author information

Department of Psychology, University College London, Gower Street, London, WC1E 6BT, UK.


This paper discusses the utility of the endophenotype approach in the study of developmental psychopathology. It is argued that endophenotype research holds considerable promise for the study of gene-brain/cognition-behaviour pathways for developmental disorders. This paper outlines the criteria for determining useful endophenotypes. Possible endophenotypes for autism are discussed as an example of an area where endophenotype research on developmental disorders may be fruitful. It is concluded that although the endophenotype approach holds promise for the study of gene-brain/cognition-behaviour pathways, much work remains to be done in order to validate endophenotype measures. It is also noted that the changing nature of any developmental psychopathology poses a particular challenge to this type of research.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center