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Anticancer Res. 2006 May-Jun;26(3B):2493-7.

Clinical effectiveness of tumor markers in squamous cell carcinoma of the larynx.

Author information

1
Department of Otolaryngology, G. Gennimatas Hospital, Athens, Greece. aegika@yahoo.gr

Abstract

BACKGROUND:

The aim of this study was to examine and compare the value of the serum tumor markers CYFRA 21-1, TPA-M, SCCA and CEA in squamous cell carcinoma (SCC) of the larynx. Moreover, their possible clinical applications were studied.

MATERIALS AND METHODS:

The serum levels of CYFRA 21-1, TPA-M, SCCA and CEA were measured in 79 patients with histologically-proven squamous cell carcinoma (SCC) of the larynx before and after treatment and in 77 healthy volunteers. The association of the results with the clinicopathological characteristics was investigated.

RESULTS:

The study showed that none of the markers revealed a significant sensitivity; TPA-M indicated a positive correlation with the grade of differentiation. CEA indicated a positive correlation only with distant metastasis.

CONCLUSION:

Among the four markers, only TPA-M may play a role in monitoring the success of therapy and follow-up in patients with SCC of the larynx.

PMID:
16821638
[Indexed for MEDLINE]
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