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J Lipid Res. 2006 Jul;47(7):1597-8. Epub 2006 Apr 27.

Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function.

Author information

1
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA. pike@wustl.edu

Abstract

The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23-28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts. What emerged from the meeting was a consensus definition of a membrane raft: "Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." This definition helps to clarify current thinking in a field that has been plagued by the heterogeneous and sometimes ephemeral nature of its subject.

PMID:
16645198
DOI:
10.1194/jlr.E600002-JLR200
[Indexed for MEDLINE]
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