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Science. 2005 Jul 8;309(5732):264-8. Epub 2005 Jun 2.

Professional antigen-presentation function by human gammadelta T Cells.

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1
Institute of Cell Biology, University of Bern, CH-3012, Switzerland.

Abstract

Human gammadelta T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells expressing the Vgamma2Vdelta2+-T cell receptor (Vdelta2+ T cells) also display principal characteristics of professional antigen-presenting cells such as dendritic cells. Thus, when activated, these cells efficiently processed and displayed antigens and provided co-stimulatory signals sufficient for strong induction of naïve alphabeta T cell proliferation and differentiation. We suggest that, upon microbial activation, Vdelta2+ T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy.

PMID:
15933162
DOI:
10.1126/science.1110267
[Indexed for MEDLINE]
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