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Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6.

Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide.

Author information

1
Institute of Preventive Medicine, National Defense Medical College, National Defense University, Taipei, Taiwan.

Abstract

Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 microM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

PMID:
15215127
PMCID:
PMC434198
DOI:
10.1128/AAC.48.7.2693-2696.2004
[Indexed for MEDLINE]
Free PMC Article

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