Send to

Choose Destination
Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8670-5. Epub 2004 May 26.

Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus.

Author information

Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.


During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8alpha(-)CD11b(-) DC subset and distinct CD8alpha(+) lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center