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Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8670-5. Epub 2004 May 26.

Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus.

Author information

1
Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia. belz@wehi.edu.au

Abstract

During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8alpha(-)CD11b(-) DC subset and distinct CD8alpha(+) lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.

PMID:
15163797
PMCID:
PMC423253
DOI:
10.1073/pnas.0402644101
[Indexed for MEDLINE]
Free PMC Article

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