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IUBMB Life. 2004 Feb;56(2):89-93.

Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters.

Author information

1
Institute for Molecular Biosciences, The University of Queensland, 4072, Australia. r.lewis@imb.uq.edu.au

Abstract

Cone snails have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in normal and diseased states. A number of these peptides have shown efficacy in vivo, including inhibitors of calcium channels, the norepinephrine transporter, nicotinic acetylcholine receptors, NMDA receptors and neurotensin receptors, with several having undergone pre-clinical or clinical development for the treatment of pain.

PMID:
15085932
DOI:
10.1080/15216540410001668055
[Indexed for MEDLINE]
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