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Biol Psychiatry. 2003 Oct 15;54(8):862-5.

Neuronavigated repetitive transcranial magnetic stimulation in patients with tinnitus: a short case series.

Author information

1
Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetstrasse 84, Regensburg 93053, Germany.

Abstract

BACKGROUND:

Clinical as well as neurophysiological and neuroimaging data suggest that chronic tinnitus resembles neuropsychiatric syndromes characterized by focal brain activation. Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been proposed as an efficient method in treating brain hyperexcitability disorders by reducing cortical excitability.

METHODS:

In three patients suffering from chronic tinnitus, the effect of magnetic resonance imaging and positron emission tomography guided neuronavigated 1 Hz rTMS on auditory cortex activity was evaluated, using a sham controlled double-blind crossover design.

RESULTS:

Two of three patients revealed clearly increased metabolic activity in circumscript areas of the primary auditory cortex (PAC), allowing a selective stimulation of these cortical areas with low-frequency rTMS. Considerable improvement in tinnitus was achieved in these patients.

CONCLUSIONS:

Neuronavigated rTMS of increased PAC activity may help to better understand the neuronal basis of chronic tinnitus and might offer a new option for treating auditory phantom perceptions like chronic tinnitus.

PMID:
14550687
[Indexed for MEDLINE]

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