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Restor Neurol Neurosci. 2003;21(3-4):171-6.

Biochemical serum markers for brain damage: a short review with emphasis on clinical utility in mild head injury.

Author information

1
Department of Neurosurgery, University Hospital of North Norway, N-9038 Tromsø, Norway. tor.ingebrightsen@unn.no

Abstract

PURPOSE:

To provide an overview of clinical research on the use of biochemical serum markers for traumatic brain injury (TBI) in the evaluation of patients with mild head injuries (MHI).

METHODS:

The MEDLINE database was searched for publications on biochemical serum markers of TBI until August 2002. Clinical studies addressing their use in MHI were reviewed.

RESULTS:

Desirable characteristics for biochemical serum markers of TBI were identified. Creatine kinase isoenzyme BB (CK-BB), neuron specific enolase (NSE) and S-100B protein have been most extensively studied. The sensitivity and specificity of CK-BB is inadequate for use as an indicator of traumatic brain injury. Serum levels of NSE do not correspond to the amount of TBI, probably because of its long (20 h) half-life. S-100B serum levels are correlated to both clinical measures of injury severity, neuroradiological findings and outcomes in several studies from different authors.

CONCLUSION:

Currently, S-100B protein is the most promising marker for evaluation of TBI in patients with MHI.

PMID:
14530579
[Indexed for MEDLINE]

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