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Microbes Infect. 2003 May;5(6):499-506.

The role of natural killer T cells and other T cell subsets against infection by the pre-erythrocytic stages of malaria parasites.

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Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA.


T cells are critical mediators of immunity to the pre-erythrocytic stages of malaria parasites. In this review, we survey the role of the various T cell subsets in combating the pre-erythrocytic stages; in particular, the role of NK T cells. Moreover, we show how studies using malaria models have revealed a unique behavior of NK T cells, namely the bridging of innate and adaptive immunity.

[Indexed for MEDLINE]

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