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Nat Rev Mol Cell Biol. 2003 May;4(5):385-96.

Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogens.

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Department of Microbiology and Immunology and Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.


Macrophages function at the front line of immune defences against incoming pathogens. But the ability of macrophages to internalize bacteria, migrate, recruit other immune cells to the site of infection and influence the nature of the immune response can provide unintended benefits for bacterial pathogens that are able to subvert or co-opt these normally effective defences. This review highlights recent advances in our understanding of the many interference strategies that are used by bacterial pathogens to undermine macrophage signalling.

[Indexed for MEDLINE]

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