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J Virol. 2002 Nov;76(21):11166-71.

The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.

Author information

1
Institut für Molekulare Medizin, Heinrich Heine-Universität, 40225 Düsseldorf, Germany.

Abstract

The influenza A virus nonstructural NS1 protein is known to modulate host cell gene expression and to inhibit double-stranded RNA (dsRNA)-mediated antiviral responses. Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.

PMID:
12368362
PMCID:
PMC136597
DOI:
10.1128/jvi.76.21.11166-11171.2002
[Indexed for MEDLINE]
Free PMC Article

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