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Chin Med J (Engl). 1998 Jun;111(6):492-5.

Effects of beta-amyloid peptide on transient outward potassium current of acutely dissociated hippocampal neurons in CA1 sector in rats.

Author information

1
Department of Neurology, First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China.

Abstract

OBJECTIVE:

To explore the mechanism of beta-amyloid peptide (beta-AP) in Alzheimer's disease at ionic channel level.

METHODS:

Hippocampal CA1 neurons of 7-21 days' rats were acutely dissociated and the effects of beta-AP on transient outward potassium current were observed by a whole-cell recording patch clamp technique.

RESULTS:

beta-AP can significantly block transient potassium current in dose-dependent, time-dependent and partly voltage-dependent manners.

CONCLUSION:

beta-AP may decrease the membrane conductance of K+ channels in hippocampal neurons, playing an important role in the pathophysiological mechanism of Alzheimer's disease.

PMID:
11245064
[Indexed for MEDLINE]

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