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J Clin Epidemiol. 2000 Dec;53(12):1209-16.

The relationship between health-related quality of life and frequency of spells in patients with syncope.

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Health Research Group, University of Calgary, 3330 Hospital Drive N. W., Calgary, T2N 4N1, Alberta, Canada.


Chronic syncope has a wide range of symptom burden, and anecdotal data suggest substantial but variable physical and psychosocial morbidity. We hypothesized that health-related quality of life (HRQL) is impaired in syncope patients and the degree of impairment is proportional to syncope frequency. The EuroQol EQ-5D was completed by 136 patients (79 female and 57 male) with mean age 40 (SD = 17) prior to assessment. HRQL was substantially impaired in syncope patients compared to population norms in all five dimensions of health measured by the EQ-5D. In patients with six or more lifetime syncopal spells there was a significant (P < 0.001) negative relationship between the frequency of spells and overall perception of health, which was not evident in those who had a history of less than six lifetime spells. These relationships were maintained after controlling for comorbid conditions.

[Indexed for MEDLINE]

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