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Viral Immunol. 2000;13(3):287-95.

Multifactorial protective mechanisms to limit viral replication in the lung of mice during primary murine cytomegalovirus infection.

Author information

1
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10010, USA.

Abstract

In this article, we investigated the protective host immune mechanisms against acute murine cytomegalovirus (MCMV) infection. For this purpose, we used various knockout mice lacking molecules, which include interferon-gamma (IFN-gamma), interferon-gamma receptor (IFN-gamma-R), interferon regulatory factor-1 (IRF-1), inducible nitric oxide synthase (iNOS), and perforin. We also used mutant mice lacking Fas molecule. When we infected these mice with MCMV and determined the viral titers in their lungs at different time points, we found that IFN-gamma, IFN-gamma-R, IRF-1, iNOS, and perforin-deficient mice developed significantly higher titers of infectious MCMV in the lung, compared to those observed in their respective wild-type controls. In the lungs of Fas-mutant mice, viral titers were similar to those obtained in wild-type mice.

PMID:
11016594
DOI:
10.1089/08828240050144626
[Indexed for MEDLINE]

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