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Trends Biochem Sci. 2000 Jul;25(7):307-11.

Calcium, a signaling molecule in the endoplasmic reticulum?

Author information

1
MRC Group in Molecular Biology of Membranes and the Department of Biochemistry, University of Alberta, Edmonton, AL, Canada T6G 2H7.

Abstract

For many years now, it has been known that Ca2+ is an important signaling molecule in the cytosol of the cell, but emerging evidence suggests that Ca2+ might also play a signaling role in the endoplasmic reticulum. For example, agonist-induced fluctuations in free Ca2+ concentration in the endoplasmic reticulum can affect many functions of the endoplasmic reticulum, including protein synthesis and modification, and interchaperone interactions.

PMID:
10871879
DOI:
10.1016/s0968-0004(00)01588-7
[Indexed for MEDLINE]

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