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J Orthop Trauma. 1999 Sep-Oct;13(7):470-6.

Influence of the design for fixation implants on local infection: experimental study of dynamic compression plates versus point contact fixators in rabbits.

Author information

1
AO ASIF Research Institute, Davos, Switzerland.

Abstract

OBJECTIVES:

Comparison of infection resistance after local bacterial challenge associated with two different designs for fixation implants: the conventional dynamic compression plate (DCP) and the point contact fixator (PC-Fix).

DESIGN:

Randomized, prospective study in experimental animals. Grouped sequential experimental procedure. Observation time was twenty-eight days, with twenty animals per group.

SETTING:

Following surgery, animals were kept without restrictions in individual hutches.

ANIMALS:

Forty White New Zealand rabbits. Thirty-eight animals, nineteen per group, were included in the final evaluation.

INTERVENTION:

Under sterile conditions, specially manufactured titanium DCP or PC-Fix of identical dimensions were fixed to rabbit tibiae. After wound closure, different concentrations of Staphylococcus aureus, between 2 x 10(4) and 2 x 10(8) colony-forming units (CFU), were inoculated percutaneously at the implant site.

MAIN OUTCOME MEASUREMENTS:

Implants, underlying bone, and surrounding soft tissues were removed under sterile conditions and quantitatively evaluated for bacterial growth. Infection was defined as positive bacterial growth at the bone-implant interface.

RESULTS:

The overall infection rate was 45 percent. The infection dose of 50 percent (ID50) was 7.08 x 10(5) CFU for the DCP group and 8.51 x 10(6) CFU for the PC-Fix group. The infection rate was 63 percent (twelve of nineteen animals) for the DCP group and 26 percent (five of nineteen animals) for the PC-Fix group. This difference was statistically significant (p = 0.022).

CONCLUSIONS:

After local bacterial challenge, we found a statistically significant difference in the infection rates depending on the implant design. The higher infection resistance associated with the PC-Fix design seems to be related to the reduced contact area at the bone-implant interface.

PMID:
10513968
[Indexed for MEDLINE]

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