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  • The following term was not found in PubMed: Nov-Dec;27.
Neurorehabil Neural Repair. 2013 Nov-Dec;27(9):864-71. doi: 10.1177/1545968313496328. Epub 2013 Jul 29.

Improving gait and balance in patients with leukoaraiosis using transcranial direct current stimulation and physical training: an exploratory study.

Author information

1
1Imperial College London, Charing Cross Hospital, London, UK.

Abstract

BACKGROUND:

Leukoaraiosis describes ischemic white matter lesions, a leading cause of gait disturbance in the elderly.

OBJECTIVE:

Our aim was to improve gait and balance in patients with leukoaraiosis by combining a single session of transcranial direct current stimulation (tDCS) and physical training (PT).

METHODS:

We delivered anodal tDCS over midline motor and premotor areas in 9 patients with leukoaraiosis. Patients underwent gait and balance training during tDCS stimulation (real/sham). This was repeated 1 week later with the stimulation crossed-over (sham/real) in a double-blind design. Assessments included gait velocity, stride length, stride length variability (primary gait outcomes), and a quantitative retropulsion test (primary balance outcome).

RESULTS:

. Combining tDCS and PT improved gait velocity, stride length, stride length variability, and balance (all at P ≤ .05). Overall, training without tDCS showed no significant effects.

CONCLUSIONS:

Combined anodal tDCS and PT improves gait and balance in this patient group, suggesting that tDCS could be an effective adjunct to PT in patients with leukoaraiosis, for whom no treatment is currently available.

KEYWORDS:

gait; leukoaraiosis; rehabilitation; small vessel disease; training; transcranial direct current stimulation; white matter

PMID:
23897903
DOI:
10.1177/1545968313496328
[Indexed for MEDLINE]

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