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See 1 citation in Clin Rehabil 2014:

Clin Rehabil. 2014 Nov;28(11):1115-24. doi: 10.1177/0269215514534277. Epub 2014 May 21.

Combining physical training with transcranial direct current stimulation to improve gait in Parkinson's disease: a pilot randomized controlled study.

Author information

1
Division of Brain Sciences, Imperial College London, London, UK Universidad de Buenos Aires, Hospital Sirio Libanés Buenos Aires, Buenos Aires, Argentina d.kaski@imperial.ac.uk.
2
Universidad de Buenos Aires, Hospital Sirio Libanés Buenos Aires, Buenos Aires, Argentina.
3
University ORL Clinic, Basel, Switzerland.
4
Department of Primary Care and Public Health, Imperial College London, London, UK.
5
Division of Brain Sciences, Imperial College London, London, UK.

Abstract

OBJECTIVE:

To improve gait and balance in patients with Parkinson's disease by combining anodal transcranial direct current stimulation with physical training.

DESIGN:

In a double-blind design, one group (physical training; n = 8) underwent gait and balance training during transcranial direct current stimulation (tDCS; real/sham). Real stimulation consisted of 15 minutes of 2 mA transcranial direct current stimulation over primary motor and premotor cortex. For sham, the current was switched off after 30 seconds. Patients received the opposite stimulation (sham/real) with physical training one week later; the second group (No physical training; n = 8) received stimulation (real/sham) but no training, and also repeated a sequential transcranial direct current stimulation session one week later (sham/real).

SETTING:

Hospital Srio Libanes, Buenos Aires, Argentina.

SUBJECTS:

Sixteen community-dwelling patients with Parkinson's disease.

INTERVENTIONS:

Transcranial direct current stimulation with and without concomitant physical training.

MAIN MEASURES:

Gait velocity (primary gait outcome), stride length, timed 6-minute walk test, Timed Up and Go Test (secondary outcomes), and performance on the pull test (primary balance outcome).

RESULTS:

Transcranial direct current stimulation with physical training increased gait velocity (mean = 29.5%, SD = 13; p < 0.01) and improved balance (pull test: mean = 50.9%, SD = 37; p = 0.01) compared with transcranial direct current stimulation alone. There was no isolated benefit of transcranial direct current stimulation alone. Although physical training improved gait velocity (mean = 15.5%, SD = 12.3; p = 0.03), these effects were comparatively less than with combined tDCS + physical therapy (p < 0.025). Greater stimulation-related improvements were seen in patients with more advanced disease.

CONCLUSIONS:

Anodal transcranial direct current stimulation during physical training improves gait and balance in patients with Parkinson's disease. Power calculations revealed that 14 patients per treatment arm (α = 0.05; power = 0.8) are required for a definitive trial.

KEYWORDS:

Cerebral cortex; Parkinson’s disease; electrical stimulation therapy; exercise therapy; gait

PMID:
24849794
DOI:
10.1177/0269215514534277
[Indexed for MEDLINE]

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