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Ultrasound Med Biol. 2019 May;45(5):1234-1242. doi: 10.1016/j.ultrasmedbio.2019.01.008. Epub 2019 Feb 15.

In Vivo Measurements of Cortical Thickness and Porosity at the Proximal Third of the Tibia Using Guided Waves: Comparison with Site-Matched Peripheral Quantitative Computed Tomography and Distal High-Resolution Peripheral Quantitative Computed Tomography.

Author information

1
Berlin-Brandenburg School for Regenerative Therapies (BSRT), Charité-Universitätsmedizin Berlin, Berlin, Germany.
2
Laboratoire d'Imagerie Biomédicale (LIB), Sorbonne University, CNRS, INSERM, Paris, France; BleuSolid, Pomponne, France.
3
Center for Muscle and Bone Research (ZMK), Charité-Universitätsmedizin Berlin, Berlin, Germany.
4
Berlin-Brandenburg School for Regenerative Therapies (BSRT), Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address: kay.raum@charite.de.
5
Laboratoire d'Imagerie Biomédicale (LIB), Sorbonne University, CNRS, INSERM, Paris, France; Escuela de Ingeniería Civil en Informática, Universidad de Valparaíso, Valparaíso, Chile.

Abstract

The aim of this study was to estimate cortical porosity (Ct.Po) and cortical thickness (Ct.Th) using 500-kHz bi-directional axial transmission (AT). Ct.ThAT and Ct.PoAT were obtained at the tibia in 15 patients from a 2-D transverse isotropic free plate model fitted to measured guided wave dispersion curves. The velocities of the first arriving signal (υFAS) and A0 mode (υA0) were also determined. Site-matched peripheral quantitative computed tomography (pQCT) provided volumetric cortical bone mineral density (Ct.vBMDpQCT) and Ct.ThpQCT. Good agreement was found between Ct.ThAT and Ct.ThpQCT (R2 = 0.62, root mean square error [RMSE] = 0.39 mm). Ct.vBMDpQCT correlated with Ct.PoAT (R2 = 0.57), υFAS (R2 = 0.43) and υA0 (R2 = 0.28). Furthermore, a significant correlation was found between AT and distal high-resolution pQCT. The measurement ofcortical parameters at the tibia using guided waves might improve the prediction of bone fractures in a cost-effective and radiation-free manner.

KEYWORDS:

Axial transmission ultrasound; Cortical bone porosity; Dual-energy X-ray absorptiometry; Guided waves; Peripheral quantitative computed tomography

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