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J Adolesc Health. 2017 Feb;60(2):229-232. doi: 10.1016/j.jadohealth.2016.10.003. Epub 2016 Dec 6.

Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa.

Author information

1
Division of Adolescent Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Division of Gynecology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: amy.divasta@childrens.harvard.edu.
2
Clinical Research Program, Boston Children's Hospital, Boston, Massachusetts; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts.
3
Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.
4
Division of Pediatric Nephrology, Stanford University School of Medicine, Palo Alto, California.
5
Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Abstract

PURPOSE:

We examined the relationships between malnutrition, lifestyle factors, and bone health in anorexia nervosa (AN) via dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT).

METHODS:

Seventy adolescent girls with AN and 132 normal-weighted controls underwent pQCT tibial measures including trabecular volumetric bone mineral density (vBMD), cortical vBMD, and cortical thickness. Participants with AN underwent DXA measures of the axial skeleton. We assessed the association of DXA and pQCT measures with clinical and lifestyle variables.

RESULTS:

Body mass index Z-score and ideal body weight percentage were positively correlated with trabecular vBMD, cortical CSA, and section modulus (p < .04). Exercise was associated with all pQCT measures but only with hip BMD by DXA. In AN, the use of antidepressants was associated with lower pQCT measures (p < .03).

CONCLUSIONS:

Antidepressants may negatively, and exercise positively, influence BMD in adolescents with eating disorders. These findings offer a provocative look at two longstanding questions.

KEYWORDS:

Anorexia nervosa; Antidepressant; DXA; Exercise; Malnutrition; Peripheral quantitative computed tomography

PMID:
27939877
PMCID:
PMC5267944
DOI:
10.1016/j.jadohealth.2016.10.003
[Indexed for MEDLINE]
Free PMC Article

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