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Bone. 2016 Feb;83:119-126. doi: 10.1016/j.bone.2015.10.018. Epub 2015 Nov 2.

Greater association of peak neuromuscular performance with cortical bone geometry, bone mass and bone strength than bone density: A study in 417 older women.

Author information

1
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany; Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia. Electronic address: belavy@gmail.com.
2
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. Electronic address: gabi.armbrecht@charite.de.
3
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. Electronic address: tilo.blenk@googlemail.com.
4
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. Electronic address: ob@promedio.eu.
5
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. Electronic address: Hendrikje.Boerst@charite.de.
6
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. Electronic address: info@dr-kocakaya.de.
7
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. Electronic address: franziska.luhn@gmx.de.
8
Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia. Electronic address: t.rantalainen@deakin.edu.au.
9
Stratec Medizintechnik GmbH, Durlacher Str. 35, 75172 Pforzheim, Germany. Electronic address: r.rawer@novotecmedical.de.
10
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. Electronic address: fe_thomasius@web.de.
11
Stratec Medizintechnik GmbH, Durlacher Str. 35, 75172 Pforzheim, Germany. Electronic address: j.willnecker@stratec-med.com.
12
Centre for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. Electronic address: dieter.felsenberg@charite.de.

Abstract

BACKGROUND:

We evaluated which aspects of neuromuscular performance are associated with bone mass, density, strength and geometry.

METHODS:

417 women aged 60-94years were examined. Countermovement jump, sit-to-stand test, grip strength, forearm and calf muscle cross-sectional area, areal bone mineral content and density (aBMC and aBMD) at the hip and lumbar spine via dual X-ray absorptiometry, and measures of volumetric vBMC and vBMD, bone geometry and section modulus at 4% and 66% of radius length and 4%, 38% and 66% of tibia length via peripheral quantitative computed tomography were performed. The first principal component of the neuromuscular variables was calculated to generate a summary neuromuscular variable. Percentage of total variance in bone parameters explained by the neuromuscular parameters was calculated. Step-wise regression was also performed.

RESULTS:

At all pQCT bone sites (radius, ulna, tibia, fibula), a greater percentage of total variance in measures of bone mass, cortical geometry and/or bone strength was explained by peak neuromuscular performance than for vBMD. Sit-to-stand performance did not relate strongly to bone parameters. No obvious differential in the explanatory power of neuromuscular performance was seen for DXA aBMC versus aBMD. In step-wise regression, bone mass, cortical morphology, and/or strength remained significant in relation to the first principal component of the neuromuscular variables. In no case was vBMD positively related to neuromuscular performance in the final step-wise regression models.

CONCLUSION:

Peak neuromuscular performance has a stronger relationship with leg and forearm bone mass and cortical geometry as well as proximal forearm section modulus than with vBMD.

KEYWORDS:

Exercise; Function; Osteoporosis; Sarcopenia

PMID:
26541093
DOI:
10.1016/j.bone.2015.10.018
[Indexed for MEDLINE]

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