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Dev Neurorehabil. 2013 Dec;16(6):391-7. doi: 10.3109/17518423.2012.762590. Epub 2013 Mar 11.

Evaluation of bone mineral density and morphology using pQCT in children after spinal cord injury.

Author information

1
Institute of Endocrinology and Diabetes, The Sydney Children's Hospitals Network , Westmead, Sydney , Australia.

Abstract

OBJECTIVE:

To evaluate the effects of spinal cord injury (SCI) on bone density and morphology in children using peripheral quantitative computer tomography (pQCT).

DESIGN:

Retrospective cohort study of 19 paediatric patients with SCI (9 paraplegics and 10 tetraplegics).

RESULTS:

There was significant reduction in tibial metaphysial volumetric bone mineral density (vBMD), diaphysial cortical cross-sectional area (CSA), cortical thickness and polar strength-strain index. There was a significant loss of calf muscle CSA. Those who were able to stand had greater trabecular vBMD, tibial cortical thickness and tibial muscle CSA Z-scores. Lower limb fractures did not occur if tibial trabecular vBMD was greater than 100 mg/cm³. Tibial geometry following SCI was more circular compared to controls.

CONCLUSIONS:

pQCT provides a valuable insight into the regional changes in bone and muscle development in children following SCI. Residual muscle function with the ability to weight bear provides a significant benefit to bone development.

PMID:
23477616
DOI:
10.3109/17518423.2012.762590
[Indexed for MEDLINE]

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