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Rev Bras Ginecol Obstet. 2018 Jun;40(6):360-368. doi: 10.1055/s-0038-1657754. Epub 2018 Jun 6.

Guidelines for HPV-DNA Testing for Cervical Cancer Screening in Brazil.

Author information

1
Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.
2
Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
3
Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
4
Universidade de Brasília, Brasília, Distrito Federal, Brazil.
5
Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro, Rio de Janeiro, Brazil.
6
Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
7
Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, da Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.

Abstract

in English, Portuguese

Evidence-based clinical guidelines ensure best practice protocols are available in health care. There is a widespread use of human papillomavirus deoxyribonucleic acid (HPV-DNA) tests in Brazil, regardless of the lack of official guidelines. On behalf of the Brazilian Association for the Lower Genital Tract Pathology and Colposcopy (ABPTGIC, in the Portuguese acronym), a team of reviewers searched for published evidence and developed a set of recommendations for the use of HPV-DNA tests in cervical cancer screening in Brazil. The product of this process was debated and consensus was sought by the participants. One concern of the authors was the inclusion of these tests in the assessment of women with cytologic atypia and women treated for cervical intraepithelial neoplasia (CIN). Testing for HPV is recommended in an organized screening scenario to identify women with precursor lesions or asymptomatic cervical cancer older than 30 years of age, and it can be performed every 5 years. It also has value after the cytology showing atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSILs) as a triage test for colposcopy, in the investigation of other cytological alterations when no abnormal findings are observed at colposcopy, seeking to exclude disease, or, further, after treatment of high-grade cervical intraepithelial neoplasia, to rule out residual disease.

PMID:
29874685
DOI:
10.1055/s-0038-1657754
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