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Items: 1 to 20 of 165

1.

Damaging de novo mutations diminish motor skills in children on the autism spectrum.

Buja A, Volfovsky N, Krieger AM, Lord C, Lash AE, Wigler M, Iossifov I.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1859-E1866. doi: 10.1073/pnas.1715427115. Epub 2018 Feb 6.

2.

Utility of Single-Cell Genomics in Diagnostic Evaluation of Prostate Cancer.

Alexander J, Kendall J, McIndoo J, Rodgers L, Aboukhalil R, Levy D, Stepansky A, Sun G, Chobardjiev L, Riggs M, Cox H, Hakker I, Nowak DG, Laze J, Llukani E, Srivastava A, Gruschow S, Yadav SS, Robinson B, Atwal G, Trotman LC, Lepor H, Hicks J, Wigler M, Krasnitz A.

Cancer Res. 2018 Jan 15;78(2):348-358. doi: 10.1158/0008-5472.CAN-17-1138. Epub 2017 Nov 27.

3.

Partial bisulfite conversion for unique template sequencing.

Kumar V, Rosenbaum J, Wang Z, Forcier T, Ronemus M, Wigler M, Levy D.

Nucleic Acids Res. 2018 Jan 25;46(2):e10. doi: 10.1093/nar/gkx1054.

4.

Measuring shared variants in cohorts of discordant siblings with applications to autism.

Ye K, Iossifov I, Levy D, Yamrom B, Buja A, Krieger AM, Wigler M.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7073-7076. doi: 10.1073/pnas.1700439114. Epub 2017 Jun 19.

5.

Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal.

Krasnitz A, Kendall J, Alexander J, Levy D, Wigler M.

Trends Mol Med. 2017 Jul;23(7):594-603. doi: 10.1016/j.molmed.2017.05.005. Epub 2017 Jun 3. Review.

6.

Indel variant analysis of short-read sequencing data with Scalpel.

Fang H, Bergmann EA, Arora K, Vacic V, Zody MC, Iossifov I, O'Rawe JA, Wu Y, Jimenez Barron LT, Rosenbaum J, Ronemus M, Lee YH, Wang Z, Dikoglu E, Jobanputra V, Lyon GJ, Wigler M, Schatz MC, Narzisi G.

Nat Protoc. 2016 Dec;11(12):2529-2548. doi: 10.1038/nprot.2016.150. Epub 2016 Nov 17.

7.

SMASH, a fragmentation and sequencing method for genomic copy number analysis.

Wang Z, Andrews P, Kendall J, Ma B, Hakker I, Rodgers L, Ronemus M, Wigler M, Levy D.

Genome Res. 2016 Jun;26(6):844-51. doi: 10.1101/gr.201491.115. Epub 2016 Apr 14.

8.

Corrigendum: Genome-wide copy number analysis of single cells.

Baslan T, Kendall J, Rodgers L, Cox H, Riggs M, Stepansky A, Troge J, Ravi K, Esposito D, Lakshmi B, Wigler M, Navin N, Hicks J.

Nat Protoc. 2016 Mar;11(3):616. doi: 10.1038/nprot0316.616b. Epub 2016 Feb 25. No abstract available.

PMID:
26914320
9.

Low load for disruptive mutations in autism genes and their biased transmission.

Iossifov I, Levy D, Allen J, Ye K, Ronemus M, Lee YH, Yamrom B, Wigler M.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5600-7. doi: 10.1073/pnas.1516376112. Epub 2015 Sep 23.

10.

Interactive analysis and assessment of single-cell copy-number variations.

Garvin T, Aboukhalil R, Kendall J, Baslan T, Atwal GS, Hicks J, Wigler M, Schatz MC.

Nat Methods. 2015 Nov;12(11):1058-60. doi: 10.1038/nmeth.3578. Epub 2015 Sep 7.

11.

Optimizing sparse sequencing of single cells for highly multiplex copy number profiling.

Baslan T, Kendall J, Ward B, Cox H, Leotta A, Rodgers L, Riggs M, D'Italia S, Sun G, Yong M, Miskimen K, Gilmore H, Saborowski M, Dimitrova N, Krasnitz A, Harris L, Wigler M, Hicks J.

Genome Res. 2015 May;25(5):714-24. doi: 10.1101/gr.188060.114. Epub 2015 Apr 9.

12.

Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA.

Jayaprakash AD, Benson EK, Gone S, Liang R, Shim J, Lambertini L, Toloue MM, Wigler M, Aaronson SA, Sachidanandam R.

Nucleic Acids Res. 2015 Feb 27;43(4):2177-87. doi: 10.1093/nar/gkv052. Epub 2015 Feb 4.

13.

Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors.

Rye IH, Lundin P, Månér S, Fjelldal R, Naume B, Wigler M, Hicks J, Børresen-Dale AL, Zetterberg A, Russnes HG.

Genes Chromosomes Cancer. 2015 Apr;54(4):235-48. doi: 10.1002/gcc.22237. Epub 2014 Dec 26.

14.

The contribution of de novo coding mutations to autism spectrum disorder.

Iossifov I, O'Roak BJ, Sanders SJ, Ronemus M, Krumm N, Levy D, Stessman HA, Witherspoon KT, Vives L, Patterson KE, Smith JD, Paeper B, Nickerson DA, Dea J, Dong S, Gonzalez LE, Mandell JD, Mane SM, Murtha MT, Sullivan CA, Walker MF, Waqar Z, Wei L, Willsey AJ, Yamrom B, Lee YH, Grabowska E, Dalkic E, Wang Z, Marks S, Andrews P, Leotta A, Kendall J, Hakker I, Rosenbaum J, Ma B, Rodgers L, Troge J, Narzisi G, Yoon S, Schatz MC, Ye K, McCombie WR, Shendure J, Eichler EE, State MW, Wigler M.

Nature. 2014 Nov 13;515(7526):216-21. doi: 10.1038/nature13908. Epub 2014 Oct 29.

15.

Facilitated sequence counting and assembly by template mutagenesis.

Levy D, Wigler M.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4632-7. doi: 10.1073/pnas.1416204111. Epub 2014 Oct 13.

16.

Accurate de novo and transmitted indel detection in exome-capture data using microassembly.

Narzisi G, O'Rawe JA, Iossifov I, Fang H, Lee YH, Wang Z, Wu Y, Lyon GJ, Wigler M, Schatz MC.

Nat Methods. 2014 Oct;11(10):1033-6. doi: 10.1038/nmeth.3069. Epub 2014 Aug 17.

17.

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells.

Dago AE, Stepansky A, Carlsson A, Luttgen M, Kendall J, Baslan T, Kolatkar A, Wigler M, Bethel K, Gross ME, Hicks J, Kuhn P.

PLoS One. 2014 Aug 1;9(8):e101777. doi: 10.1371/journal.pone.0101777. eCollection 2014.

18.

The role of de novo mutations in the genetics of autism spectrum disorders.

Ronemus M, Iossifov I, Levy D, Wigler M.

Nat Rev Genet. 2014 Feb;15(2):133-41. doi: 10.1038/nrg3585. Epub 2014 Jan 16. Review.

PMID:
24430941
19.

The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease.

Warburton D, Ronemus M, Kline J, Jobanputra V, Williams I, Anyane-Yeboa K, Chung W, Yu L, Wong N, Awad D, Yu CY, Leotta A, Kendall J, Yamrom B, Lee YH, Wigler M, Levy D.

Hum Genet. 2014 Jan;133(1):11-27. doi: 10.1007/s00439-013-1353-9. Epub 2013 Aug 25.

20.

Target inference from collections of genomic intervals.

Krasnitz A, Sun G, Andrews P, Wigler M.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2271-8. doi: 10.1073/pnas.1306909110. Epub 2013 Jun 6.

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