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Items: 1 to 20 of 228

1.

Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells.

Kryvenko V, Wessendorf M, Morty RE, Herold S, Seeger W, Vagin O, Dada LA, Sznajder JI, Vadász I.

Int J Mol Sci. 2020 Feb 21;21(4). pii: E1467. doi: 10.3390/ijms21041467.

2.

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans.

Shigemura M, Lecuona E, Angulo M, Dada LA, Edwards MB, Welch LC, Casalino-Matsuda SM, Sporn PHS, Vadász I, Helenius IT, Nader GA, Gruenbaum Y, Sharabi K, Cummins E, Taylor C, Bharat A, Gottardi CJ, Beitel GJ, Kaminski N, Budinger GRS, Berdnikovs S, Sznajder JI.

Sci Rep. 2019 Dec 3;9(1):18251. doi: 10.1038/s41598-019-54683-0.

3.

Linear ubiquitin assembly complex regulates lung epithelial-driven responses during influenza infection.

Brazee PL, Morales-Nebreda L, Magnani ND, Garcia JG, Misharin AV, Ridge KM, Budinger GRS, Iwai K, Dada LA, Sznajder JI.

J Clin Invest. 2020 Mar 2;130(3):1301-1314. doi: 10.1172/JCI128368.

4.

Influenza A Virus Infection Induces Apical Redistribution of Na+, K+-ATPase in Lung Epithelial Cells In Vitro and In Vivo.

Peteranderl C, Kuznetsova I, Schulze J, Hardt M, Lecuona E, Sznajder JI, Vadász I, Morty RE, Pleschka S, Wolff T, Herold S.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):395-398. doi: 10.1165/rcmb.2019-0096LE. No abstract available.

PMID:
31469298
5.

Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.

Amarelle L, Katzen J, Shigemura M, Welch LC, Cajigas H, Peteranderl C, Celli D, Herold S, Lecuona E, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1094-L1106. doi: 10.1152/ajplung.00173.2018. Epub 2019 Mar 20.

PMID:
30892074
6.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

7.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC.

8.

Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

Radigan KA, Nicholson TT, Welch LC, Chi M, Amarelle L, Angulo M, Shigemura M, Shigemura A, Runyan CE, Morales-Nebreda L, Perlman H, Ceco E, Lecuona E, Dada LA, Misharin AV, Mutlu GM, Sznajder JI, Budinger GRS.

J Immunol. 2019 Jan 15;202(2):484-493. doi: 10.4049/jimmunol.1701433. Epub 2018 Dec 7.

9.

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis.

Sala MA, Balderas-Martínez YI, Buendía-Roldan I, Abdala-Valencia H, Nam K, Jain M, Bhorade S, Bharat A, Reyfman PA, Ridge KM, Pardo A, Sznajder JI, Budinger GRS, Misharin AV, Selman M.

Respir Res. 2018 Nov 26;19(1):233. doi: 10.1186/s12931-018-0932-7.

10.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

11.

Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells.

Casalino-Matsuda SM, Wang N, Ruhoff PT, Matsuda H, Nlend MC, Nair A, Szleifer I, Beitel GJ, Sznajder JI, Sporn PHS.

Sci Rep. 2018 Sep 10;8(1):13508. doi: 10.1038/s41598-018-32008-x.

12.

Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.

Shigemura M, Lecuona E, Angulo M, Homma T, Rodríguez DA, Gonzalez-Gonzalez FJ, Welch LC, Amarelle L, Kim SJ, Kaminski N, Budinger GRS, Solway J, Sznajder JI.

Sci Transl Med. 2018 Sep 5;10(457). pii: eaat1662. doi: 10.1126/scitranslmed.aat1662.

13.

Ubiquitin-proteasome signaling in lung injury.

Magnani ND, Dada LA, Sznajder JI.

Transl Res. 2018 Aug;198:29-39. doi: 10.1016/j.trsl.2018.04.003. Epub 2018 Apr 23. Review.

14.

Future Research Directions in Pneumonia. NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. doi: 10.1164/rccm.201801-0139WS.

15.

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.

Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J.

J Biol Chem. 2018 Jan 5;293(1):271-284. doi: 10.1074/jbc.RA117.000440. Epub 2017 Nov 8.

16.

HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Magnani ND, Dada LA, Queisser MA, Brazee PL, Welch LC, Anekalla KR, Zhou G, Vagin O, Misharin AV, Budinger GRS, Iwai K, Ciechanover AJ, Sznajder JI.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10178-E10186. doi: 10.1073/pnas.1713563114. Epub 2017 Nov 6.

17.

Stretching to Understand How Proteostasis and the Unfolded Protein Response Regulate Lung Injury.

Lecuona E, Sznajder JI.

Am J Respir Cell Mol Biol. 2017 Aug;57(2):143-144. doi: 10.1165/rcmb.2017-0170ED. No abstract available.

18.

Gas Exchange Disturbances Regulate Alveolar Fluid Clearance during Acute Lung Injury.

Vadász I, Sznajder JI.

Front Immunol. 2017 Jul 4;8:757. doi: 10.3389/fimmu.2017.00757. eCollection 2017. Review.

19.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

20.

Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.

Zhou Q, Dai J, Chen T, Dada LA, Zhang X, Zhang W, DeCamp MM, Winn RA, Sznajder JI, Zhou G.

Cell Signal. 2017 Oct;38:49-59. doi: 10.1016/j.cellsig.2017.06.016. Epub 2017 Jun 24.

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