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Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.

Zhou D, Zhao Y, Kotecha A, Fry EE, Kelly JT, Wang X, Rao Z, Rowlands DJ, Ren J, Stuart DI.

Nat Microbiol. 2018 Dec 10. doi: 10.1038/s41564-018-0319-z. [Epub ahead of print]


Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1.

Cao L, Zhang R, Liu T, Sun Z, Hu M, Sun Y, Cheng L, Guo Y, Fu S, Hu J, Li X, Yu C, Wang H, Chen H, Li X, Fry EE, Stuart DI, Qian P, Lou Z, Rao Z.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13087-13092. doi: 10.1073/pnas.1814309115. Epub 2018 Dec 4.


Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.

Elegheert J, Behiels E, Bishop B, Scott S, Woolley RE, Griffiths SC, Byrne EFX, Chang VT, Stuart DI, Jones EY, Siebold C, Aricescu AR.

Nat Protoc. 2018 Dec;13(12):2991-3017. doi: 10.1038/s41596-018-0075-9.


Redundant Late Domain Functions of Tandem VP2 YPX3L Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus.

González-López O, Rivera-Serrano EE, Hu F, Hensley L, McKnight KL, Ren J, Stuart DI, Fry EE, Lemon SM.

J Virol. 2018 Nov 12;92(23). pii: e01308-18. doi: 10.1128/JVI.01308-18. Print 2018 Dec 1.


Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate.

Kotecha A, Perez-Martin E, Harvey Y, Zhang F, Ilca SL, Fry EE, Jackson B, Maree F, Scott K, Hecksel CW, Harmsen MM, Mioulet V, Wood B, Juleff N, Stuart DI, Charleston B, Seago J.

Sci Rep. 2018 Sep 12;8(1):13654. doi: 10.1038/s41598-018-31856-x.


Machining protein microcrystals for structure determination by electron diffraction.

Duyvesteyn HME, Kotecha A, Ginn HM, Hecksel CW, Beale EV, de Haas F, Evans G, Zhang P, Chiu W, Stuart DI.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9569-9573. doi: 10.1073/pnas.1809978115. Epub 2018 Aug 31.


Generation and characterisation of recombinant FMDV antibodies: Applications for advancing diagnostic and laboratory assays.

Shimmon G, Kotecha A, Ren J, Asfor AS, Newman J, Berryman S, Cottam EM, Gold S, Tuthill TJ, King DP, Brocchi E, King AMQ, Owens R, Fry EE, Stuart DI, Burman A, Jackson T.

PLoS One. 2018 Aug 16;13(8):e0201853. doi: 10.1371/journal.pone.0201853. eCollection 2018.


Hepatitis A Virus Capsid Structure.

Stuart DI, Ren J, Wang X, Rao Z, Fry EE.

Cold Spring Harb Perspect Med. 2018 Jul 23. pii: a031807. doi: 10.1101/cshperspect.a031807. [Epub ahead of print]


Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71.

Zhu L, Xu K, Wang N, Cao L, Wu J, Gao Q, Fry EE, Stuart DI, Rao Z, Wang J, Wang X.

MBio. 2018 Jul 3;9(4). pii: e01013-18. doi: 10.1128/mBio.01013-18.


Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.

Zhao Y, Ren J, Fry EE, Xiao J, Townsend AR, Stuart DI.

J Med Chem. 2018 Jun 14;61(11):4938-4945. doi: 10.1021/acs.jmedchem.8b00350. Epub 2018 May 21.


Where is crystallography going?

Grimes JM, Hall DR, Ashton AW, Evans G, Owen RL, Wagner A, McAuley KE, von Delft F, Orville AM, Sorensen T, Walsh MA, Ginn HM, Stuart DI.

Acta Crystallogr D Struct Biol. 2018 Feb 1;74(Pt 2):152-166. doi: 10.1107/S2059798317016709. Epub 2018 Feb 1. Review.


Towards in cellulo virus crystallography.

Duyvesteyn HME, Ginn HM, Pietilä MK, Wagner A, Hattne J, Grimes JM, Hirvonen E, Evans G, Parsy ML, Sauter NK, Brewster AS, Huiskonen JT, Stuart DI, Sutton G, Bamford DH.

Sci Rep. 2018 Feb 28;8(1):3771. doi: 10.1038/s41598-018-21693-3.


Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection.

Ren J, Zhao Y, Fry EE, Stuart DI.

J Med Chem. 2018 Feb 8;61(3):724-733. doi: 10.1021/acs.jmedchem.7b01249. Epub 2018 Jan 16.


Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer's and cat allergy.

Zeltins A, West J, Zabel F, El Turabi A, Balke I, Haas S, Maudrich M, Storni F, Engeroff P, Jennings GT, Kotecha A, Stuart DI, Foerster J, Bachmann MF.

NPJ Vaccines. 2017 Oct 23;2:30. doi: 10.1038/s41541-017-0030-8. eCollection 2017.


Building the atomic model of a boreal lake virus of unknown fold in a 3.9 Å cryo-EM map.

De Colibus L, Stuart DI.

J Struct Biol. 2018 Apr;202(1):94-99. doi: 10.1016/j.jsb.2017.10.010. Epub 2017 Oct 27.


The slip-and-slide algorithm: a refinement protocol for detector geometry.

Ginn HM, Stuart DI.

J Synchrotron Radiat. 2017 Nov 1;24(Pt 6):1152-1162. doi: 10.1107/S1600577517013327. Epub 2017 Oct 18.


Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation.

Malik N, Kotecha A, Gold S, Asfor A, Ren J, Huiskonen JT, Tuthill TJ, Fry EE, Stuart DI.

PLoS Pathog. 2017 Sep 22;13(9):e1006607. doi: 10.1371/journal.ppat.1006607. eCollection 2017 Sep.


Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine.

Marsian J, Fox H, Bahar MW, Kotecha A, Fry EE, Stuart DI, Macadam AJ, Rowlands DJ, Lomonossoff GP.

Nat Commun. 2017 Aug 15;8(1):245. doi: 10.1038/s41467-017-00090-w.


Virus found in a boreal lake links ssDNA and dsDNA viruses.

Laanto E, Mäntynen S, De Colibus L, Marjakangas J, Gillum A, Stuart DI, Ravantti JJ, Huiskonen JT, Sundberg LR.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8378-8383. doi: 10.1073/pnas.1703834114. Epub 2017 Jul 17.


High-speed fixed-target serial virus crystallography.

Roedig P, Ginn HM, Pakendorf T, Sutton G, Harlos K, Walter TS, Meyer J, Fischer P, Duman R, Vartiainen I, Reime B, Warmer M, Brewster AS, Young ID, Michels-Clark T, Sauter NK, Kotecha A, Kelly J, Rowlands DJ, Sikorsky M, Nelson S, Damiani DS, Alonso-Mori R, Ren J, Fry EE, David C, Stuart DI, Wagner A, Meents A.

Nat Methods. 2017 Aug;14(8):805-810. doi: 10.1038/nmeth.4335. Epub 2017 Jun 19.

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