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Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes.

Lugenbiel P, Govorov K, Rahm AK, Wieder T, Gramlich D, Syren P, Weiberg N, Seyler C, Katus HA, Thomas D.

Cell Physiol Biochem. 2018;49(1):65-77. doi: 10.1159/000492840. Epub 2018 Aug 22.


Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells.

Schweizer PA, Darche FF, Ullrich ND, Geschwill P, Greber B, Rivinius R, Seyler C, Müller-Decker K, Draguhn A, Utikal J, Koenen M, Katus HA, Thomas D.

Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4.


TranslatiOnal Registry for CardiomyopatHies (TORCH) - rationale and first results.

Seyler C, Meder B, Weis T, Schwaneberg T, Weitmann K, Hoffmann W, Katus HA, Dösch A.

ESC Heart Fail. 2017 Aug;4(3):209-215. doi: 10.1002/ehf2.12145. Epub 2017 Mar 14.


Data privacy management and data quality monitoring in the German Centre for Cardiovascular Research's multicentre TranslatiOnal Registry for CardiomyopatHies (DZHK-TORCH).

Schwaneberg T, Weitmann K, Dösch A, Seyler C, Bahls T, Geidel L, Stahl D, Lee M, Kraus M, Katus HA, Hoffmann W.

ESC Heart Fail. 2017 Nov;4(4):440-447. doi: 10.1002/ehf2.12168. Epub 2017 Jul 18.


Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.

Scherer D, Schworm B, Seyler C, Xynogalos P, Scholz EP, Thomas D, Katus HA, Zitron E.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Jul;390(7):701-710. doi: 10.1007/s00210-017-1372-5. Epub 2017 Apr 2.


Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A.

Seyler C, Scherer D, Köpple C, Kulzer M, Korkmaz S, Xynogalos P, Thomas D, Kaya Z, Scholz E, Backs J, Karle C, Katus HA, Zitron E.

Naunyn Schmiedebergs Arch Pharmacol. 2017 May;390(5):493-503. doi: 10.1007/s00210-017-1344-9. Epub 2017 Mar 22.


Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference.

Koepple C, Scherer D, Seyler C, Scholz E, Thomas D, Katus HA, Zitron E.

J Pharmacol Exp Ther. 2017 May;361(2):209-218. doi: 10.1124/jpet.116.238287. Epub 2017 Feb 10.


TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.

Lugenbiel P, Wenz F, Syren P, Geschwill P, Govorov K, Seyler C, Frank D, Schweizer PA, Franke J, Weis T, Bruehl C, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D.

Basic Res Cardiol. 2017 Jan;112(1):8. doi: 10.1007/s00395-016-0597-7. Epub 2016 Dec 22.


Efficacy, High Procedural Safety And Rapid Optimization Of Cryoballoon Atrial Fibrillation Ablation In The Hands Of A New Operator.

Scholz E, Lugenbiel P, Schweizer PA, Xynogalos P, Seyler C, Zitron E, Becker R, Katus HA, Thomas D.

J Atr Fibrillation. 2016 Feb 29;8(5):1341. doi: 10.4022/jafib.1341. eCollection 2016 Feb-Mar.


miR-19b Regulates Ventricular Action Potential Duration in Zebrafish.

Benz A, Kossack M, Auth D, Seyler C, Zitron E, Juergensen L, Katus HA, Hassel D.

Sci Rep. 2016 Nov 2;6:36033. doi: 10.1038/srep36033.


Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.

Scherer D, Seyler C, Xynogalos P, Scholz EP, Thomas D, Backs J, Andrassy M, Völkers M, Karle CA, Katus HA, Zitron E.

PLoS One. 2016 May 23;11(5):e0156181. doi: 10.1371/journal.pone.0156181. eCollection 2016.


Therapeutic targeting of two-pore-domain potassium (K(2P)) channels in the cardiovascular system.

Wiedmann F, Schmidt C, Lugenbiel P, Staudacher I, Rahm AK, Seyler C, Schweizer PA, Katus HA, Thomas D.

Clin Sci (Lond). 2016 May;130(9):643-50. doi: 10.1042/CS20150533. Review.


Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action.

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP.

Drug Des Devel Ther. 2015 Feb 16;9:867-77. doi: 10.2147/DDDT.S72765. eCollection 2015.


Magnetized laboratory plasma jets: experiment and simulation.

Schrafel P, Bell K, Greenly J, Seyler C, Kusse B.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jan;91(1):013110. Epub 2015 Jan 30.


Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action.

Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP.

Drug Des Devel Ther. 2014 Nov 7;8:2263-71. doi: 10.2147/DDDT.S70461. eCollection 2014.


Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.

Xynogalos P, Seyler C, Scherer D, Koepple C, Scholz EP, Thomas D, Katus HA, Zitron E.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Dec;387(12):1153-61. doi: 10.1007/s00210-014-1045-6. Epub 2014 Sep 4.


Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.

Kisselbach J, Seyler C, Schweizer PA, Gerstberger R, Becker R, Katus HA, Thomas D.

Br J Pharmacol. 2014 Dec;171(23):5182-94. doi: 10.1111/bph.12596. Epub 2014 Aug 28.


The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D.

J Am Coll Cardiol. 2014 Aug 26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.


Vernakalant activates human cardiac K(2P)17.1 background K(+) channels.

Seyler C, Schweizer PA, Zitron E, Katus HA, Thomas D.

Biochem Biophys Res Commun. 2014 Aug 29;451(3):415-20. doi: 10.1016/j.bbrc.2014.07.133. Epub 2014 Aug 7.


Isoenzyme-specific regulation of cardiac Kv1.5/Kvβ1.2 ion channel complex by protein kinase C: central role of PKCβII.

Fischer F, Vonderlin N, Seyler C, Zitron E, Korkmaz S, Szabó G, Thomas D, Katus HA, Scholz EP.

Naunyn Schmiedebergs Arch Pharmacol. 2014 May;387(5):469-76. doi: 10.1007/s00210-014-0965-5. Epub 2014 Feb 28.


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