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Items: 1 to 20 of 21

1.

Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?

Kasal A, Buděšínský M, Mareš P, Krištofíková Z, Leitão AJ, Sá e Melo ML, Silva MM.

Steroids. 2016 Jan;105:12-8. doi: 10.1016/j.steroids.2015.11.007. Epub 2015 Nov 26.

PMID:
26631551
2.

Oxysterols and related sterols: Chemical, biochemical and biological aspects.

Sá e Melo ML, Cruz Silva MM, Iuliano L, Lizard G.

Steroids. 2015 Jul;99(Pt B):117-8. doi: 10.1016/j.steroids.2015.05.006. No abstract available.

PMID:
26055148
3.

Anticancer steroids: linking natural and semi-synthetic compounds.

Salvador JA, Carvalho JF, Neves MA, Silvestre SM, Leitão AJ, Silva MM, Sá e Melo ML.

Nat Prod Rep. 2013 Feb;30(2):324-74. doi: 10.1039/c2np20082a. Review.

PMID:
23151898
4.

Androstane-3β,5α,6β,17β-tetrol tri-hydrate.

Andrade LC, de Almeida MJ, Paixão JA, Carvalho JF, Sá E Melo ML.

Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1643-4. doi: 10.1107/S1600536811021349. Epub 2011 Jun 11.

5.

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.

Carvalho JF, Silva MM, Moreira JN, Simões S, Sá E Melo ML.

J Med Chem. 2011 Sep 22;54(18):6375-93. doi: 10.1021/jm200803d. Epub 2011 Aug 24.

PMID:
21797280
6.

3β,5α,6β-Trihy-droxy-androstan-17-one.

Andrade LC, de Almeida MJ, Paixão JA, Carvalho JF, Sá E Melo ML.

Acta Crystallogr Sect E Struct Rep Online. 2011 May 1;67(Pt 5):o1056-7. doi: 10.1107/S1600536811011706. Epub 2011 Apr 7.

7.

Ligand-guided optimization of CXCR4 homology models for virtual screening using a multiple chemotype approach.

Neves MA, Simões S, Sá e Melo ML.

J Comput Aided Mol Des. 2010 Dec;24(12):1023-33. doi: 10.1007/s10822-010-9393-x. Epub 2010 Oct 20.

PMID:
20960031
8.

Sterols as anticancer agents: synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis.

Carvalho JF, Silva MM, Moreira JN, Simões S, Sá e Melo ML.

J Med Chem. 2010 Nov 11;53(21):7632-8. doi: 10.1021/jm1007769.

PMID:
20931970
9.

6-[(4-Fluorophenyl)(1H-imidazol-1-yl)methyl]-1,3-benzodioxol-5-ol and 6-[(4-methoxyphenyl)(1H-imidazol-1-yl)methyl]-1,3-benzodioxol-5-ol.

Andrade LC, Paixão JA, deAlmeida MJ, Neves MA, Sá e Melo ML.

Acta Crystallogr C. 2010 Oct;66(Pt 10):o499-502. doi: 10.1107/S0108270110034773. Epub 2010 Sep 10.

PMID:
20921615
10.

6beta-Methyl-B-norandrostenedione.

Andrade LC, de Almeida MJ, Neves MA, Dinis TC, Sá e Melo ML.

Acta Crystallogr C. 2010 Apr;66(Pt 4):o185-6. doi: 10.1107/S0108270110005871. Epub 2010 Mar 6.

PMID:
20354306
11.

An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors.

Neves MA, Dinis TC, Colombo G, Sá e Melo ML.

Eur J Med Chem. 2009 Oct;44(10):4121-7. doi: 10.1016/j.ejmech.2009.05.003. Epub 2009 May 19.

PMID:
19500885
12.

Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols.

Carvalho JF, Cruz Silva MM, Moreira JN, Simões S, Sá E Melo ML.

J Med Chem. 2009 Jul 9;52(13):4007-19. doi: 10.1021/jm9003973.

PMID:
19473028
13.

Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors.

Neves MA, Dinis TC, Colombo G, Sá e Melo ML.

J Med Chem. 2009 Jan 8;52(1):143-50. doi: 10.1021/jm800945c.

PMID:
19072235
14.

Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols.

Neves MA, Dinis TC, Colombo G, Sá e Melo ML.

ChemMedChem. 2007 Dec;2(12):1750-62.

PMID:
17910019
15.

3 beta,7 alpha,12 alpha-triformyloxy-24-nor-5 beta-chol-22-ene.

Andrade LC, Paixão JA, de Almeida MJ, da Silva EJ, Sá e Melo ML, Roleira FM.

Acta Crystallogr C. 2004 Jan;60(Pt 1):o82-3. Epub 2003 Dec 20.

PMID:
14712055
16.

Acute and chronic toxicity of dimethylsulfoxide to Daphnia magna.

Barbosa IR, Martins RM, Sá E Melo ML, Soares AM.

Bull Environ Contam Toxicol. 2003 Jun;70(6):1264-8. No abstract available.

PMID:
12756470
17.

X-ray and deuterium labeling studies on the abnormal ring cleavages of a 5 beta-epoxide precursor of formestane.

da Silva EJ, Roleira FM, Sá e Melo ML, Neves AS, Paixão JA, de Almeida MJ, Silva MR, Andrade LC.

Steroids. 2002 Mar;67(3-4):311-9.

PMID:
11856555
18.

16alpha,17alpha-Epoxy-20-oxopregn-5-en-3beta-yl acetate.

Andrade LC, Paixão JA, de Almeida MJ, Martins RM, Soares HI, Morais GJ, Moreno MJ, Sá e Melo ML, Campos Neves AS.

Acta Crystallogr C. 2001 May;57(Pt 5):587-9. Epub 2001 May 15.

PMID:
11353261
19.

Synthesis and biological evaluation of two new radiolabelled estrogens: [125I](E)-3-methoxy-17alpha-iodovinylestra-1,3,5(10),6-tetraen-17beta-ol and.

Melo e Silva MC, Patrćio L, Gano L, Sá e Melo ML, Inohae E, Mataka S, Thiemann T.

Appl Radiat Isot. 2001 Feb;54(2):227-39. Erratum in: Appl Radiat Isot 2001 Dec;55(6):899.

PMID:
11200884
20.

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