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N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with PGE2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.

Ann Neurol. 2018 Oct 7. doi: 10.1002/ana.25356. [Epub ahead of print]


Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo.

Jeitner TM, Pinto JT, Cooper AJL.

Biosci Rep. 2018 Sep 5;38(5). pii: BSR20180691. doi: 10.1042/BSR20180691. Print 2018 Oct 31.


Assessment of Dry Powder Inhaler Carrier Targeted Design: A Comparative Case Study of Diverse Anomeric Compositions and Physical Properties of Lactose.

Pinto JT, Zellnitz S, Guidi T, Roblegg E, Paudel A.

Mol Pharm. 2018 Jul 2;15(7):2827-2839. doi: 10.1021/acs.molpharmaceut.8b00333. Epub 2018 Jun 19.


Sulfur amino acid restriction-induced changes in redox-sensitive proteins are associated with slow protein synthesis rates.

Nichenametla SN, Mattocks DAL, Malloy VL, Pinto JT.

Ann N Y Acad Sci. 2018 Apr;1418(1):80-94. doi: 10.1111/nyas.13556. Epub 2018 Jan 29.


Application of open-access databases to determine functional connectivity between resveratrol-binding protein QR2 and colorectal carcinoma.

Doonan BB, Schaafsma E, Pinto JT, Wu JM, Hsieh TC.

In Vitro Cell Dev Biol Anim. 2017 Aug;53(7):575-578. doi: 10.1007/s11626-017-0174-x. Epub 2017 Jun 23.


How does secondary processing affect the physicochemical properties of inhalable salbutamol sulphate particles? A temporal investigation.

Pinto JT, Radivojev S, Zellnitz S, Roblegg E, Paudel A.

Int J Pharm. 2017 Aug 7;528(1-2):416-428. doi: 10.1016/j.ijpharm.2017.06.027. Epub 2017 Jun 12.


Fluorination at the 4 position alters the substrate behavior of L-glutamine and L-glutamate: Implications for positron emission tomography of neoplasias.

Jeitner TM, Kristoferson E, Azcona JA, Pinto JT, Stalnecker C, Erickson JW, Kung HF, Li J, Ploessl K, Cooper AJL.

J Fluor Chem. 2016 Dec;192(A):58-67. doi: 10.1016/j.jfluchem.2016.10.008. Epub 2016 Oct 20.


Chymase-dependent production of angiotensin II: an old enzyme in old hearts.

Froogh G, Pinto JT, Le Y, Kandhi S, Aleligne Y, Huang A, Sun D.

Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H223-H231. doi: 10.1152/ajpheart.00534.2016. Epub 2016 Nov 4.



Pinto JT, Zempleni J.

Adv Nutr. 2016 Sep 15;7(5):973-5. doi: 10.3945/an.116.012716. Print 2016 Sep. No abstract available.


Erratum to: ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.

Cooper AJ, Shurubor YI, Dorai T, Pinto JT, Isakova EP, Deryabina YI, Denton TT, Krasnikov BF.

Amino Acids. 2015 Dec;47(12):2671-2. doi: 10.1007/s00726-015-2115-x. No abstract available.


ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.

Cooper AJ, Shurubor YI, Dorai T, Pinto JT, Isakova EP, Deryabina YI, Denton TT, Krasnikov BF.

Amino Acids. 2016 Jan;48(1):1-20. doi: 10.1007/s00726-015-2061-7. Epub 2015 Aug 11. Review. Erratum in: Amino Acids. 2015 Dec;47(12):2671-2.


Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane.

Wu JM, Oraee A, Doonan BB, Pinto JT, Hsieh TC.

Exp Hematol Oncol. 2016 Sep 13;5(1):27. doi: 10.1186/s40164-016-0056-z. eCollection 2015.


Role of homocysteinylation of ACE in endothelial dysfunction of arteries.

Huang A, Pinto JT, Froogh G, Kandhi S, Qin J, Wolin MS, Hintze TH, Sun D.

Am J Physiol Heart Circ Physiol. 2015 Jan 15;308(2):H92-100. doi: 10.1152/ajpheart.00577.2014. Epub 2014 Nov 21.


Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.

Sleiman SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J, Wagner FF, Basso M, Coppola G, Pinto JT, Holson EB, Ratan RR.

J Neurosci. 2014 Oct 22;34(43):14328-37. doi: 10.1523/JNEUROSCI.1010-14.2014. Erratum in: J Neurosci. 2015 Jan 7;35(1):438.


HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.

Kang Y, Nian H, Rajendran P, Kim E, Dashwood WM, Pinto JT, Boardman LA, Thibodeau SN, Limburg PJ, Löhr CV, Bisson WH, Williams DE, Ho E, Dashwood RH.

Cell Death Dis. 2014 Oct 16;5:e1476. doi: 10.1038/cddis.2014.422.


Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine.

Pinto JT, Krasnikov BF, Alcutt S, Jones ME, Dorai T, Villar MT, Artigues A, Li J, Cooper AJ.

J Biol Chem. 2014 Nov 7;289(45):30950-61. doi: 10.1074/jbc.M114.591461. Epub 2014 Sep 17.


Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats.

Csiszár A, Csiszar A, Pinto JT, Gautam T, Kleusch C, Hoffmann B, Tucsek Z, Toth P, Sonntag WE, Ungvari Z.

J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):303-13. doi: 10.1093/gerona/glu029. Epub 2014 Mar 18.


From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D.

Pinto JT, Cooper AJ.

Adv Nutr. 2014 Mar 1;5(2):144-63. doi: 10.3945/an.113.005181. Review.


Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia.

Sinha I, Allen JE, Pinto JT, Sinha R.

Cancer Med. 2014 Apr;3(2):252-64. doi: 10.1002/cam4.198. Epub 2014 Feb 7.

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