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Items: 1 to 20 of 429

1.

Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach.

Vivian-Griffiths T, Baker E, Schmidt KM, Bracher-Smith M, Walters J, Artemiou A, Holmans P, O'Donovan MC, Owen MJ, Pocklington A, Escott-Price V.

Am J Med Genet B Neuropsychiatr Genet. 2018 Dec 4. doi: 10.1002/ajmg.b.32705. [Epub ahead of print]

PMID:
30516002
2.

Effects of pathogenic CNVs on physical traits in participants of the UK Biobank.

Owen D, Bracher-Smith M, Kendall KM, Rees E, Einon M, Escott-Price V, Owen MJ, O'Donovan MC, Kirov G.

BMC Genomics. 2018 Dec 4;19(1):867. doi: 10.1186/s12864-018-5292-7.

3.

Developmental Contributions of Schizophrenia Risk Alleles and Childhood Peer Victimization to Early-Onset Mental Health Trajectories.

Riglin L, Hammerton G, Heron J, Collishaw S, Arseneault L, Thapar AK, Maughan B, O'Donovan MC, Thapar A.

Am J Psychiatry. 2018 Nov 29:appiajp201818010075. doi: 10.1176/appi.ajp.2018.18010075. [Epub ahead of print]

PMID:
30486671
4.

Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study.

Richards A, Horwood J, Boden J, Kennedy M, Sellers R, Riglin L, Mistry S, Jones H, Smith DJ, Zammit S, Owen M, O'Donovan MC, Harold GT.

Br J Psychiatry. 2018 Nov 26:1-7. doi: 10.1192/bjp.2018.227. [Epub ahead of print]

PMID:
30472973
5.

Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis.

Rees E, Carrera N, Morgan J, Hambridge K, Escott-Price V, Pocklington AJ, Richards AL, Pardiñas AF; GROUP Investigators, McDonald C, Donohoe G, Morris DW, Kenny E, Kelleher E, Gill M, Corvin A, Kirov G, Walters JTR, Holmans P, Owen MJ, O'Donovan MC.

Biol Psychiatry. 2018 Oct 1. pii: S0006-3223(18)31878-X. doi: 10.1016/j.biopsych.2018.08.022. [Epub ahead of print]

6.

Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders.

O'Brien HE, Hannon E, Hill MJ, Toste CC, Robertson MJ, Morgan JE, McLaughlin G, Lewis CM, Schalkwyk LC, Hall LS, Pardiñas AF, Owen MJ, O'Donovan MC, Mill J, Bray NJ.

Genome Biol. 2018 Nov 12;19(1):194. doi: 10.1186/s13059-018-1567-1.

7.

Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia.

Bergen SE, Ploner A, Howrigan D; CNV Analysis Group and the Schizophrenia Working Group of the Psychiatric Genomics Consortium, O'Donovan MC, Smoller JW, Sullivan PF, Sebat J, Neale B, Kendler KS.

Am J Psychiatry. 2018 Nov 5:appiajp201817040467. doi: 10.1176/appi.ajp.2018.17040467. [Epub ahead of print]

PMID:
30392412
8.

Medical consequences of pathogenic CNVs in adults: analysis of the UK Biobank.

Crawford K, Bracher-Smith M, Owen D, Kendall KM, Rees E, Pardiñas AF, Einon M, Escott-Price V, Walters JTR, O'Donovan MC, Owen MJ, Kirov G.

J Med Genet. 2018 Oct 20. pii: jmedgenet-2018-105477. doi: 10.1136/jmedgenet-2018-105477. [Epub ahead of print]

PMID:
30343275
9.

Characterizing Developmental Trajectories and the Role of Neuropsychiatric Genetic Risk Variants in Early-Onset Depression.

Rice F, Riglin L, Thapar AK, Heron J, Anney R, O'Donovan MC, Thapar A.

JAMA Psychiatry. 2018 Oct 14. doi: 10.1001/jamapsychiatry.2018.3338. [Epub ahead of print]

PMID:
30326013
10.

Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species.

Sykes L, Haddon J, Lancaster TM, Sykes A, Azzouni K, Ihssen N, Moon AL, Lin TE, Linden DE, Owen MJ, O'Donovan MC, Humby T, Wilkinson LS, Thomas KL, Hall J.

Schizophr Bull. 2018 Oct 10. doi: 10.1093/schbul/sby146. [Epub ahead of print]

PMID:
30304534
11.

Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU-GEI study.

Quattrone D, Di Forti M, Gayer-Anderson C, Ferraro L, Jongsma HE, Tripoli G, La Cascia C, La Barbera D, Tarricone I, Berardi D, Szöke A, Arango C, Lasalvia A, Tortelli A, Llorca PM, de Haan L, Velthorst E, Bobes J, Bernardo M, Sanjuán J, Santos JL, Arrojo M, Del-Ben CM, Menezes PR, Selten JP; EU-GEI WP2 Group, Jones PB, Kirkbride JB, Richards AL, O'Donovan MC, Sham PC, Vassos E, Rutten BP, van Os J, Morgan C, Lewis CM, Murray RM, Reininghaus U.

Psychol Med. 2018 Oct 4:1-14. doi: 10.1017/S0033291718002131. [Epub ahead of print]

PMID:
30282569
12.

Investigating the genetic architecture of general and specific psychopathology in adolescence.

Jones HJ, Heron J, Hammerton G, Stochl J, Jones PB, Cannon M, Smith GD, Holmans P, Lewis G, Linden DEJ, O'Donovan MC, Owen MJ, Walters J, Zammit S; 23 and Me Research Team.

Transl Psychiatry. 2018 Aug 8;8(1):145. doi: 10.1038/s41398-018-0204-9.

13.

Genetic identification of brain cell types underlying schizophrenia.

Skene NG, Bryois J, Bakken TE, Breen G, Crowley JJ, Gaspar HA, Giusti-Rodriguez P, Hodge RD, Miller JA, Muñoz-Manchado AB, O'Donovan MC, Owen MJ, Pardiñas AF, Ryge J, Walters JTR, Linnarsson S, Lein ES; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sullivan PF, Hjerling-Leffler J.

Nat Genet. 2018 Jun;50(6):825-833. doi: 10.1038/s41588-018-0129-5. Epub 2018 May 21.

PMID:
29785013
14.

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, Blackwood DRH, Bryois J, Buttenschøn HN, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen JH, Clarke TK, Coleman JIR, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford GE, Crowley CA, Dashti HS, Davies G, Deary IJ, Degenhardt F, Derks EM, Direk N, Dolan CV, Dunn EC, Eley TC, Eriksson N, Escott-Price V, Kiadeh FHF, Finucane HK, Forstner AJ, Frank J, Gaspar HA, Gill M, Giusti-Rodríguez P, Goes FS, Gordon SD, Grove J, Hall LS, Hannon E, Hansen CS, Hansen TF, Herms S, Hickie IB, Hoffmann P, Homuth G, Horn C, Hottenga JJ, Hougaard DM, Hu M, Hyde CL, Ising M, Jansen R, Jin F, Jorgenson E, Knowles JA, Kohane IS, Kraft J, Kretzschmar WW, Krogh J, Kutalik Z, Lane JM, Li Y, Li Y, Lind PA, Liu X, Lu L, MacIntyre DJ, MacKinnon DF, Maier RM, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland SE, Mehta D, Middeldorp CM, Mihailov E, Milaneschi Y, Milani L, Mill J, Mondimore FM, Montgomery GW, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard MG, Nyholt DR, O'Reilly PF, Oskarsson H, Owen MJ, Painter JN, Pedersen CB, Pedersen MG, Peterson RE, Pettersson E, Peyrot WJ, Pistis G, Posthuma D, Purcell SM, Quiroz JA, Qvist P, Rice JP, Riley BP, Rivera M, Saeed Mirza S, Saxena R, Schoevers R, Schulte EC, Shen L, Shi J, Shyn SI, Sigurdsson E, Sinnamon GBC, Smit JH, Smith DJ, Stefansson H, Steinberg S, Stockmeier CA, Streit F, Strohmaier J, Tansey KE, Teismann H, Teumer A, Thompson W, Thomson PA, Thorgeirsson TE, Tian C, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden AG, Umbricht D, Van der Auwera S, van Hemert AM, Viktorin A, Visscher PM, Wang Y, Webb BT, Weinsheimer SM, Wellmann J, Willemsen G, Witt SH, Wu Y, Xi HS, Yang J, Zhang F; eQTLGen; 23andMe, Arolt V, Baune BT, Berger K, Boomsma DI, Cichon S, Dannlowski U, de Geus ECJ, DePaulo JR, Domenici E, Domschke K, Esko T, Grabe HJ, Hamilton SP, Hayward C, Heath AC, Hinds DA, Kendler KS, Kloiber S, Lewis G, Li QS, Lucae S, Madden PFA, Magnusson PK, Martin NG, McIntosh AM, Metspalu A, Mors O, Mortensen PB, Müller-Myhsok B, Nordentoft M, Nöthen MM, O'Donovan MC, Paciga SA, Pedersen NL, Penninx BWJH, Perlis RH, Porteous DJ, Potash JB, Preisig M, Rietschel M, Schaefer C, Schulze TG, Smoller JW, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PF; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

Nat Genet. 2018 May;50(5):668-681. doi: 10.1038/s41588-018-0090-3. Epub 2018 Apr 26.

15.

A data-driven investigation of relationships between bipolar psychotic symptoms and schizophrenia genome-wide significant genetic loci.

Leonenko G, Di Florio A, Allardyce J, Forty L, Knott S, Jones L, Gordon-Smith K, Owen MJ, Jones I, Walters J, Craddock N, O'Donovan MC, Escott-Price V.

Am J Med Genet B Neuropsychiatr Genet. 2018 Jun;177(4):468-475. doi: 10.1002/ajmg.b.32635. Epub 2018 Apr 19.

16.

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.

Gusev A, Mancuso N, Won H, Kousi M, Finucane HK, Reshef Y, Song L, Safi A; Schizophrenia Working Group of the Psychiatric Genomics Consortium, McCarroll S, Neale BM, Ophoff RA, O'Donovan MC, Crawford GE, Geschwind DH, Katsanis N, Sullivan PF, Pasaniuc B, Price AL.

Nat Genet. 2018 Apr;50(4):538-548. doi: 10.1038/s41588-018-0092-1. Epub 2018 Apr 9.

17.

Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype-Based Approach.

Lancaster TM, Dimitriadis SL, Tansey KE, Perry G, Ihssen N, Jones DK, Singh KD, Holmans P, Pocklington A, Davey Smith G, Zammit S, Hall J, O'Donovan MC, Owen MJ, Linden DE.

Schizophr Bull. 2018 Mar 28. doi: 10.1093/schbul/sby037. [Epub ahead of print]

PMID:
29608775
18.

POLARIS: Polygenic LD-adjusted risk score approach for set-based analysis of GWAS data.

Baker E, Schmidt KM, Sims R, O'Donovan MC, Williams J, Holmans P, Escott-Price V, Consortium WTG.

Genet Epidemiol. 2018 Jun;42(4):366-377. doi: 10.1002/gepi.22117. Epub 2018 Mar 12.

19.

Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort.

Escott-Price V, Smith DJ, Kendall K, Ward J, Kirov G, Owen MJ, Walters J, O'Donovan MC.

Psychol Med. 2018 Mar 4:1-6. doi: 10.1017/S0033291718000454. [Epub ahead of print]

PMID:
29501066
20.

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, MacCabe JH, McCarroll SA, Baune BT, Breen G, Byrne EM, Dannlowski U, Eley TC, Hayward C, Martin NG, McIntosh AM, Plomin R, Porteous DJ, Wray NR, Caballero A, Geschwind DH, Huckins LM, Ruderfer DM, Santiago E, Sklar P, Stahl EA, Won H, Agerbo E, Als TD, Andreassen OA, Bækvad-Hansen M, Mortensen PB, Pedersen CB, Børglum AD, Bybjerg-Grauholm J, Djurovic S, Durmishi N, Pedersen MG, Golimbet V, Grove J, Hougaard DM, Mattheisen M, Molden E, Mors O, Nordentoft M, Pejovic-Milovancevic M, Sigurdsson E, Silagadze T, Hansen CS, Stefansson K, Stefansson H, Steinberg S, Tosato S, Werge T; GERAD1 Consortium:; CRESTAR Consortium:, Collier DA, Rujescu D, Kirov G, Owen MJ, O'Donovan MC, Walters JTR; GERAD1 Consortium; CRESTAR Consortium; GERAD1 Consortium; CRESTAR Consortium.

Nat Genet. 2018 Mar;50(3):381-389. doi: 10.1038/s41588-018-0059-2. Epub 2018 Feb 26.

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