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Items: 1 to 20 of 230

1.

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM.

Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5.

PMID:
30644384
2.

SAR by kinetics for drug discovery in protein misfolding diseases.

Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10245-10250. doi: 10.1073/pnas.1807884115. Epub 2018 Sep 26.

3.

Protein stabilization with retained function of monellin using a split GFP system.

Weiffert T, Linse S.

Sci Rep. 2018 Aug 24;8(1):12763. doi: 10.1038/s41598-018-31177-z.

4.

Ganglioside lipids accelerate α-synuclein amyloid formation.

Gaspar R, Pallbo J, Weininger U, Linse S, Sparr E.

Biochim Biophys Acta Proteins Proteom. 2018 Aug 2. pii: S1570-9639(18)30116-X. doi: 10.1016/j.bbapap.2018.07.004. [Epub ahead of print]

5.

Disaggregation of gold nanoparticles by Daphnia magna.

Mattsson K, Aguilar R, Torstensson O, Perry D, Bernfur K, Linse S, Hansson LA, Åkerfeldt KS, Cedervall T.

Nanotoxicology. 2018 Jul 27:1-16. doi: 10.1080/17435390.2018.1485982. [Epub ahead of print]

PMID:
30053796
6.

Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.

Månsson C, van Cruchten RTP, Weininger U, Yang X, Cukalevski R, Arosio P, Dobson CM, Knowles T, Akke M, Linse S, Emanuelsson C.

Biochemistry. 2018 Aug 14;57(32):4891-4902. doi: 10.1021/acs.biochem.8b00353. Epub 2018 Jul 30.

PMID:
30024736
7.

Secondary nucleation in amyloid formation.

Törnquist M, Michaels TCT, Sanagavarapu K, Yang X, Meisl G, Cohen SIA, Knowles TPJ, Linse S.

Chem Commun (Camb). 2018 Aug 2;54(63):8667-8684. doi: 10.1039/c8cc02204f. Review.

PMID:
29978862
8.

Protein-protein interactions in AQP regulation - biophysical characterization of AQP0-CaM and AQP2-LIP5 complex formation.

Kreida S, Roche JV, Olsson C, Linse S, Törnroth-Horsefield S.

Faraday Discuss. 2018 Sep 28;209(0):35-54. doi: 10.1039/c8fd00065d.

PMID:
29972182
9.

Simplifying G Protein-Coupled Receptor Isolation with a Calcium-Dependent Fragment Complementation Affinity System.

Mhurchú NN, Zoubak L, McGauran G, Linse S, Yeliseev A, O'Connell DJ.

Biochemistry. 2018 Jul 31;57(30):4383-4390. doi: 10.1021/acs.biochem.8b00469. Epub 2018 Jul 17.

PMID:
29956929
10.

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations.

Yang X, Meisl G, Frohm B, Thulin E, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5849-E5858. doi: 10.1073/pnas.1803539115. Epub 2018 Jun 12.

11.

Kinetic Analysis of Amyloid Formation.

Meisl G, Michaels TCT, Linse S, Knowles TPJ.

Methods Mol Biol. 2018;1779:181-196. doi: 10.1007/978-1-4939-7816-8_12.

PMID:
29886534
12.

Cyanylated Cysteine Reports Site-Specific Changes at Protein-Protein-Binding Interfaces Without Perturbation.

Dalton SR, Vienneau AR, Burstein SR, Xu RJ, Linse S, Londergan CH.

Biochemistry. 2018 Jul 3;57(26):3702-3712. doi: 10.1021/acs.biochem.8b00283. Epub 2018 Jun 5.

13.

Production and Use of Recombinant Aβ for Aggregation Studies.

O'Malley TT, Linse S, Walsh DM.

Methods Mol Biol. 2018;1777:307-320. doi: 10.1007/978-1-4939-7811-3_19.

PMID:
29744844
14.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
15.

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S.

Nat Chem. 2018 May;10(5):523-531. doi: 10.1038/s41557-018-0023-x. Epub 2018 Mar 26.

16.

Conformational Ensembles of Calmodulin Revealed by Nonperturbing Site-Specific Vibrational Probe Groups.

Kelly KL, Dalton SR, Wai RB, Ramchandani K, Xu RJ, Linse S, Londergan CH.

J Phys Chem A. 2018 Mar 22;122(11):2947-2955. doi: 10.1021/acs.jpca.8b00475. Epub 2018 Mar 9.

17.

Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces.

Tesei G, Hellstrand E, Sanagavarapu K, Linse S, Sparr E, Vácha R, Lund M.

Langmuir. 2018 Jan 30;34(4):1266-1273. doi: 10.1021/acs.langmuir.7b03155. Epub 2018 Jan 17.

18.

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification.

Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S.

Q Rev Biophys. 2017 Jan;50:e6. doi: 10.1017/S0033583516000172.

PMID:
29233218
19.

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.

Saar KL, Zhang Y, Müller T, Kumar CP, Devenish S, Lynn A, Łapińska U, Yang X, Linse S, Knowles TPJ.

Lab Chip. 2017 Dec 19;18(1):162-170. doi: 10.1039/c7lc00797c.

PMID:
29192926
20.

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ.

Chem Sci. 2017 Oct 1;8(10):7087-7097. doi: 10.1039/c7sc01965c. Epub 2017 Aug 31.

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