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Items: 1 to 20 of 215

1.

Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.

Kumar R, Peterson K, Misini Ignjatović M, Leffler H, Ryde U, Nilsson UJ, Logan DT.

Org Biomol Chem. 2019 Jan 11. doi: 10.1039/c8ob02888e. [Epub ahead of print]

PMID:
30632578
2.

Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding.

Verteramo ML, Stenström O, Misini Ignjatovic M, Caldararu O, Olsson MA, Manzoni F, Leffler H, Oksanen E, Logan DT, Nilsson UJ, Ryde U, Akke M.

J Am Chem Soc. 2019 Jan 8. doi: 10.1021/jacs.8b11099. [Epub ahead of print]

PMID:
30618244
3.

Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin-glycan specificities in a natural context.

Nielsen MI, Stegmayr J, Grant OC, Yang Z, Nilsson UJ, Boos I, Carlsson MC, Woods RJ, Unverzagt C, Leffler H, Wandall HH.

J Biol Chem. 2018 Dec 28;293(52):20249-20262. doi: 10.1074/jbc.RA118.004636. Epub 2018 Nov 1.

PMID:
30385505
4.

Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain.

Pal KB, Mahanti M, Huang X, Persson S, Sundin AP, Zetterberg FR, Oredsson S, Leffler H, Nilsson UJ.

Org Biomol Chem. 2018 Aug 29;16(34):6295-6305. doi: 10.1039/c8ob01354c.

PMID:
30117507
5.

The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin.

Huang X, Borgström B, Stegmayr J, Abassi Y, Kruszyk M, Leffler H, Persson L, Albinsson S, Massoumi R, Scheblykin IG, Hegardt C, Oredsson S, Strand D.

ACS Cent Sci. 2018 Jun 27;4(6):760-767. doi: 10.1021/acscentsci.8b00257. Epub 2018 Jun 14.

6.

Galectins at a glance.

Johannes L, Jacob R, Leffler H.

J Cell Sci. 2018 May 1;131(9). pii: jcs208884. doi: 10.1242/jcs.208884. Review.

7.

Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.

Noresson AL, Aurelius O, Öberg CT, Engström O, Sundin AP, Håkansson M, Stenström O, Akke M, Logan DT, Leffler H, Nilsson UJ.

Chem Sci. 2017 Dec 4;9(4):1014-1021. doi: 10.1039/c7sc04749e. eCollection 2018 Jan 28.

8.

Different angioregulatory activity of monovalent galectin-9 isoforms.

Aanhane E, Schulkens IA, Heusschen R, Castricum K, Leffler H, Griffioen AW, Thijssen VL.

Angiogenesis. 2018 Aug;21(3):545-555. doi: 10.1007/s10456-018-9607-8. Epub 2018 Mar 2.

PMID:
29500586
9.

Galectin-3 type-C self-association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function.

Sundqvist M, Welin A, Elmwall J, Osla V, Nilsson UJ, Leffler H, Bylund J, Karlsson A.

J Leukoc Biol. 2018 Feb;103(2):341-353. doi: 10.1002/JLB.3A0317-110R. Epub 2018 Jan 10.

PMID:
29345346
10.

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.

Peterson K, Kumar R, Stenström O, Verma P, Verma PR, Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ.

J Med Chem. 2018 Feb 8;61(3):1164-1175. doi: 10.1021/acs.jmedchem.7b01626. Epub 2018 Jan 11.

11.

Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions.

Zetterberg FR, Peterson K, Johnsson RE, Brimert T, Håkansson M, Logan DT, Leffler H, Nilsson UJ.

ChemMedChem. 2018 Jan 22;13(2):133-137. doi: 10.1002/cmdc.201700744. Epub 2018 Jan 15.

PMID:
29194992
12.

Spindle pole cohesion requires glycosylation-mediated localization of NuMA.

Magescas J, Sengmanivong L, Viau A, Mayeux A, Dang T, Burtin M, Nilsson UJ, Leffler H, Poirier F, Terzi F, Delacour D.

Sci Rep. 2017 May 3;7(1):1474. doi: 10.1038/s41598-017-01614-6.

13.

Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis.

Chen WS, Cao Z, Leffler H, Nilsson UJ, Panjwani N.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):9-20. doi: 10.1167/iovs.16-20009.

14.

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C.

Manzoni F, Saraboji K, Sprenger J, Kumar R, Noresson AL, Nilsson UJ, Leffler H, Fisher SZ, Schrader TE, Ostermann A, Coates L, Blakeley MP, Oksanen E, Logan DT.

Acta Crystallogr D Struct Biol. 2016 Nov 1;72(Pt 11):1194-1202. Epub 2016 Oct 28.

15.

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model.

Rajput VK, MacKinnon A, Mandal S, Collins P, Blanchard H, Leffler H, Sethi T, Schambye H, Mukhopadhyay B, Nilsson UJ.

J Med Chem. 2016 Sep 8;59(17):8141-7. doi: 10.1021/acs.jmedchem.6b00957. Epub 2016 Aug 23.

PMID:
27500311
16.

Erratum: Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.

Chen WS, Cao Z, Sugaya S, Lopez MJ, Sendra VG, Laver N, Leffler H, Nilsson UJ, Fu J, Song J, Xia L, Hamrah P, Panjwani N.

Nat Commun. 2016 Jul 19;7:12063. doi: 10.1038/ncomms12063. No abstract available.

17.

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.

Delaine T, Collins P, MacKinnon A, Sharma G, Stegmayr J, Rajput VK, Mandal S, Cumpstey I, Larumbe A, Salameh BA, Kahl-Knutsson B, van Hattum H, van Scherpenzeel M, Pieters RJ, Sethi T, Schambye H, Oredsson S, Leffler H, Blanchard H, Nilsson UJ.

Chembiochem. 2016 Sep 15;17(18):1759-70. doi: 10.1002/cbic.201600285. Epub 2016 Aug 12.

PMID:
27356186
18.

Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans.

Stegmayr J, Lepur A, Kahl-Knutson B, Aguilar-Moncayo M, Klyosov AA, Field RA, Oredsson S, Nilsson UJ, Leffler H.

J Biol Chem. 2016 Jun 17;291(25):13318-34. doi: 10.1074/jbc.M116.721464. Epub 2016 Apr 26.

19.

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.

Chen WS, Cao Z, Sugaya S, Lopez MJ, Sendra VG, Laver N, Leffler H, Nilsson UJ, Fu J, Song J, Xia L, Hamrah P, Panjwani N.

Nat Commun. 2016 Apr 12;7:11302. doi: 10.1038/ncomms11302. Erratum in: Nat Commun. 2016 Jul 19;7:12063.

20.

Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR.

Ippel H, Miller MC, Vértesy S, Zheng Y, Cañada FJ, Suylen D, Umemoto K, Romanò C, Hackeng T, Tai G, Leffler H, Kopitz J, André S, Kübler D, Jiménez-Barbero J, Oscarson S, Gabius HJ, Mayo KH.

Glycobiology. 2016 Aug;26(8):888-903. doi: 10.1093/glycob/cww021. Epub 2016 Feb 23.

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