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Items: 1 to 20 of 65

1.

Methotrexate-Loaded Solid Lipid Nanoparticles: Protein Functionalization to Improve Brain Biodistribution.

Muntoni E, Martina K, Marini E, Giorgis M, Lazzarato L, Salaroglio IC, Riganti C, Lanotte M, Battaglia L.

Pharmaceutics. 2019 Feb 2;11(2). pii: E65. doi: 10.3390/pharmaceutics11020065.

2.

A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light.

Parisi C, Failla M, Fraix A, Rescifina A, Rolando B, Lazzarato L, Cardile V, Graziano ACE, Fruttero R, Gasco A, Sortino S.

Bioorg Chem. 2018 Dec 20;85:18-22. doi: 10.1016/j.bioorg.2018.12.027. [Epub ahead of print]

PMID:
30599409
3.

Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells.

Riganti C, Contino M, Guglielmo S, Perrone MG, Salaroglio IC, Milosevic V, Giampietro R, Leonetti F, Rolando B, Lazzarato L, Colabufo NA, Fruttero R.

J Med Chem. 2018 Dec 25. doi: 10.1021/acs.jmedchem.8b01655. [Epub ahead of print]

PMID:
30584838
4.

Anti-Pseudomonas activity of 3-nitro-4-phenylfuroxan.

Orlandi VT, Bolognese F, Rolando B, Guglielmo S, Lazzarato L, Fruttero R.

Microbiology. 2018 Dec;164(12):1557-1566. doi: 10.1099/mic.0.000730. Epub 2018 Oct 9.

PMID:
30300122
5.

Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells.

Gazzano E, Lazzarato L, Rolando B, Kopecka J, Guglielmo S, Costamagna C, Chegaev K, Riganti C.

Front Pharmacol. 2018 Jun 4;9:580. doi: 10.3389/fphar.2018.00580. eCollection 2018.

6.

Aceclofenac-Galactose Conjugate: Design, Synthesis, Characterization, and Pharmacological and Toxicological Evaluations.

Magliocca S, De Caro C, Lazzarato L, Russo R, Rolando B, Chegaev K, Marini E, Nieddu M, Burrai L, Boatto G, Cristiano C, Marabello D, Gazzano E, Riganti C, Sodano F, Rimoli MG.

Mol Pharm. 2018 Aug 6;15(8):3101-3110. doi: 10.1021/acs.molpharmaceut.8b00195. Epub 2018 Jun 27.

PMID:
29912563
7.

Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor.

Sodano F, Rolando B, Spyrakis F, Failla M, Lazzarato L, Gazzano E, Riganti C, Fruttero R, Gasco A, Sortino S.

ChemMedChem. 2018 Jun 20;13(12):1238-1245. doi: 10.1002/cmdc.201800088. Epub 2018 May 8.

PMID:
29633541
8.

Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors.

Atlante S, Chegaev K, Cencioni C, Guglielmo S, Marini E, Borretto E, Gaetano C, Fruttero R, Spallotta F, Lazzarato L.

Eur J Med Chem. 2018 Jan 20;144:612-625. doi: 10.1016/j.ejmech.2017.12.047. Epub 2017 Dec 15.

PMID:
29289885
9.

Galactosylated Pro-Drug of Ursodeoxycholic Acid: Design, Synthesis, Characterization, and Pharmacological Effects in a Rat Model of Estrogen-Induced Cholestasis.

Di Guida F, Pirozzi C, Magliocca S, Santoro A, Lama A, Russo R, Nieddu M, Burrai L, Boatto G, Mollica MP, Sodano F, Lazzarato L, Chegaev K, Meli R, Raso GM, Rimoli MG.

Mol Pharm. 2018 Jan 2;15(1):21-30. doi: 10.1021/acs.molpharmaceut.7b00626. Epub 2017 Nov 28.

PMID:
29140706
10.

A Molecular Hybrid for Mitochondria-Targeted NO Photodelivery.

Sodano F, Gazzano E, Fraix A, Rolando B, Lazzarato L, Russo M, Blangetti M, Riganti C, Fruttero R, Gasco A, Sortino S.

ChemMedChem. 2018 Jan 8;13(1):87-96. doi: 10.1002/cmdc.201700608. Epub 2017 Nov 30.

PMID:
29110418
11.

gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension.

Blangetti M, Rolando B, Marini E, Chegaev K, Guglielmo S, Lazzarato L, Lucarini L, Masini E, Fruttero R.

ACS Med Chem Lett. 2017 Sep 13;8(10):1054-1059. doi: 10.1021/acsmedchemlett.7b00264. eCollection 2017 Oct 12.

12.

Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.

Dos Santos Fernandes GF, de Souza PC, Moreno-Viguri E, Santivañez-Veliz M, Paucar R, Pérez-Silanes S, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Man Chin C, da Silva PB, Chorilli M, Solcia MC, Ribeiro CM, Silva CSP, Marino LB, Bosquesi PL, Hunt DM, de Carvalho LPS, de Souza Costa CA, Cho SH, Wang Y, Franzblau SG, Pavan FR, Dos Santos JL.

J Med Chem. 2017 Oct 26;60(20):8647-8660. doi: 10.1021/acs.jmedchem.7b01332. Epub 2017 Oct 16.

13.

Furoxan Nitric Oxide Donors Disperse Pseudomonas aeruginosa Biofilms, Accelerate Growth, and Repress Pyoverdine Production.

Poh WH, Barraud N, Guglielmo S, Lazzarato L, Rolando B, Fruttero R, Rice SA.

ACS Chem Biol. 2017 Aug 18;12(8):2097-2106. doi: 10.1021/acschembio.7b00256. Epub 2017 Jun 29.

PMID:
28628310
14.

A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light.

Blangetti M, Fraix A, Lazzarato L, Marini E, Rolando B, Sodano F, Fruttero R, Gasco A, Sortino S.

Chemistry. 2017 Jul 6;23(38):9026-9029. doi: 10.1002/chem.201701889. Epub 2017 Jun 9.

PMID:
28543638
15.

New furoxan derivatives for the treatment of ocular hypertension.

Blangetti M, Rolando B, Chegaev K, Guglielmo S, Lazzarato L, Durante M, Masini E, Almirante N, Bastia E, Impagnatiello F, Fruttero R, Gasco A.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):479-483. doi: 10.1016/j.bmcl.2016.12.041. Epub 2016 Dec 18.

16.

Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis.

Fernandes GFDS, de Souza PC, Marino LB, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Chung MC, Pavan FR, Dos Santos JL.

Eur J Med Chem. 2016 Nov 10;123:523-531. doi: 10.1016/j.ejmech.2016.07.039. Epub 2016 Jul 21.

PMID:
27508879
17.

Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein.

Guglielmo S, Lazzarato L, Contino M, Perrone MG, Chegaev K, Carrieri A, Fruttero R, Colabufo NA, Gasco A.

J Med Chem. 2016 Jul 28;59(14):6729-38. doi: 10.1021/acs.jmedchem.6b00252. Epub 2016 Jul 7.

PMID:
27336199
18.

H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance.

Chegaev K, Rolando B, Cortese D, Gazzano E, Buondonno I, Lazzarato L, Fanelli M, Hattinger CM, Serra M, Riganti C, Fruttero R, Ghigo D, Gasco A.

J Med Chem. 2016 May 26;59(10):4881-9. doi: 10.1021/acs.jmedchem.6b00184. Epub 2016 May 5.

19.

A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression.

Guglielmo S, Contino M, Lazzarato L, Perrone MG, Blangetti M, Fruttero R, Colabufo NA.

ChemMedChem. 2016 Feb 17;11(4):374-6. doi: 10.1002/cmdc.201500538. Epub 2016 Jan 21.

PMID:
26797828
20.

Light-Tunable Generation of Singlet Oxygen and Nitric Oxide with a Bichromophoric Molecular Hybrid: a Bimodal Approach to Killing Cancer Cells.

Fraix A, Blangetti M, Guglielmo S, Lazzarato L, Marino N, Cardile V, Graziano AC, Manet I, Fruttero R, Gasco A, Sortino S.

ChemMedChem. 2016 Jun 20;11(12):1371-9. doi: 10.1002/cmdc.201500396. Epub 2015 Nov 5.

PMID:
26537319

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