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Items: 1 to 20 of 276

1.

Special Issue: Kinase inhibitors.

Koch P, Laufer S.

Molecules. 2018 Jul 22;23(7). pii: E1818. doi: 10.3390/molecules23071818. No abstract available.

2.

Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones.

Herrmann S, Schübel T, Costa FN, Barbosa MLC, Ferreira FF, Dias TLMF, Araújo MV, Alexandre-Moreira MS, Lima LM, Laufer S, Barreiro EJ.

An Acad Bras Cienc. 2018;90(1 Suppl 2):1073-1088. doi: 10.1590/0001-3765201820170796.

3.

In vitro activities of Ceiba speciosa (A.St.-Hil) Ravenna aqueous stem bark extract.

Dörr JA, Bitencourt S, Bortoluzzi L, Alves C, Silva J, Stoll S, Pinteus S, Boligon AA, Santos RCV, Laufer S, Pedrosa R, Goettert MI.

Nat Prod Res. 2018 May 24:1-4. doi: 10.1080/14786419.2018.1478823. [Epub ahead of print]

PMID:
29792358
4.

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.

5.

Improving diagnosis in healthcare: Local versus national adoption of recommended guidelines for the clinical breast examination.

Nathwani JN, Garren A, Laufer S, Kwan C, Pugh CM.

Am J Surg. 2018 Jun;215(6):995-999. doi: 10.1016/j.amjsurg.2017.11.030. Epub 2017 Dec 5.

PMID:
29229379
6.

Residents' response to bleeding during a simulated robotic surgery task.

Walker JL, Nathwani JN, Mohamadipanah H, Laufer S, Jocewicz FF, Gwillim E, Pugh CM.

J Surg Res. 2017 Dec;220:385-390. doi: 10.1016/j.jss.2017.07.023. Epub 2017 Sep 1.

PMID:
29180207
7.

From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors.

Heider F, Haun U, Döring E, Kudolo M, Sessler C, Albrecht W, Laufer S, Koch P.

Molecules. 2017 Oct 14;22(10). pii: E1729. doi: 10.3390/molecules22101729.

8.

NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation.

Blaess M, Bibak N, Claus RA, Kohl M, Bonaterra GA, Kinscherf R, Laufer S, Deigner HP.

Eur J Med Chem. 2018 Jun 10;153:73-104. doi: 10.1016/j.ejmech.2017.09.021. Epub 2017 Sep 21.

PMID:
29031494
9.

The 16th Berlin Summer School - Psychiatry as a Science and as a Profession: Physical Activity, Exercise and Mental Disorders.

Dumitru MM, Szczegielniak AR, Anastasova Z, Acar M, Vyglazova O, Laufer S, Kukic S, Janicijevic SM, Lučev N, Pavalache C, Dvoracek B.

Psychiatr Danub. 2017 Sep;29(3):387-388. No abstract available.

10.

P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes.

Al-Maghout T, Pelzl L, Sahu I, Sukkar B, Hosseinzadeh Z, Gutti R, Laufer S, Voelkl J, Pieske B, Gawaz M, Lang F.

Cell Physiol Biochem. 2017;42(6):2169-2181. doi: 10.1159/000479992. Epub 2017 Aug 15.

11.

Progress towards a public chemogenomic set for protein kinases and a call for contributions.

Drewry DH, Wells CI, Andrews DM, Angell R, Al-Ali H, Axtman AD, Capuzzi SJ, Elkins JM, Ettmayer P, Frederiksen M, Gileadi O, Gray N, Hooper A, Knapp S, Laufer S, Luecking U, Michaelides M, Müller S, Muratov E, Denny RA, Saikatendu KS, Treiber DK, Zuercher WJ, Willson TM.

PLoS One. 2017 Aug 2;12(8):e0181585. doi: 10.1371/journal.pone.0181585. eCollection 2017.

12.

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.

Pace S, Pergola C, Dehm F, Rossi A, Gerstmeier J, Troisi F, Pein H, Schaible AM, Weinigel C, Rummler S, Northoff H, Laufer S, Maier TJ, Rådmark O, Samuelsson B, Koeberle A, Sautebin L, Werz O.

J Clin Invest. 2017 Aug 1;127(8):3167-3176. doi: 10.1172/JCI92885. Epub 2017 Jul 24.

13.

Substituted Benzamides from Anti-inflammatory and p38 Kinase Inhibitors to Antitubercular Activity: Design, Synthesis and Screening.

Kulkarni R, Mitkari U, Achaiah G, Laufer S, Bikshapti DVRN, Chandrashekar VM, Gurav PB, Joshi SJ, Chipade VD.

Mini Rev Med Chem. 2018;18(17):1486-1497. doi: 10.2174/1389557517666170707105416.

PMID:
28685700
14.

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.

Günther M, Lategahn J, Juchum M, Döring E, Keul M, Engel J, Tumbrink HL, Rauh D, Laufer S.

J Med Chem. 2017 Jul 13;60(13):5613-5637. doi: 10.1021/acs.jmedchem.7b00316. Epub 2017 Jun 21.

PMID:
28603991
15.

Proteasome Activation by Small Molecules.

Leestemaker Y, de Jong A, Witting KF, Penning R, Schuurman K, Rodenko B, Zaal EA, van de Kooij B, Laufer S, Heck AJR, Borst J, Scheper W, Berkers CR, Ovaa H.

Cell Chem Biol. 2017 Jun 22;24(6):725-736.e7. doi: 10.1016/j.chembiol.2017.05.010. Epub 2017 May 25.

16.

Differentiation of cardiomyocytes and generation of human engineered heart tissue.

Breckwoldt K, Letuffe-Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, Benzin A, Klampe B, Reinsch MC, Laufer S, Shibamiya A, Prondzynski M, Mearini G, Schade D, Fuchs S, Neuber C, Krämer E, Saleem U, Schulze ML, Rodriguez ML, Eschenhagen T, Hansen A.

Nat Protoc. 2017 Jun;12(6):1177-1197. doi: 10.1038/nprot.2017.033. Epub 2017 May 11.

PMID:
28492526
17.

Modeling Touch and Palpation Using Autoregressive Models.

Laufer S, Pugh CM, Van Veen BD, Laufer S, Pugh CM, Van Veen BD, Laufer S, Van Veen BD, Pugh CM.

IEEE Trans Biomed Eng. 2018 Jul;65(7):1585-1594. doi: 10.1109/TBME.2017.2701401. Epub 2017 May 5.

PMID:
28489529
18.

Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping.

Juchum M, Günther M, Döring E, Sievers-Engler A, Lämmerhofer M, Laufer S.

J Med Chem. 2017 Jun 8;60(11):4636-4656. doi: 10.1021/acs.jmedchem.7b00178. Epub 2017 May 23.

PMID:
28482151
19.

Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.

Wentsch HK, Walter NM, Bührmann M, Mayer-Wrangowski S, Rauh D, Zaman GJR, Willemsen-Seegers N, Buijsman RC, Henning M, Dauch D, Zender L, Laufer S.

Angew Chem Int Ed Engl. 2017 May 2;56(19):5363-5367. doi: 10.1002/anie.201701185. Epub 2017 Apr 11.

PMID:
28397331
20.

In Vivo Hypoxia PET Imaging Quantifies the Severity of Arthritic Joint Inflammation in Line with Overexpression of Hypoxia-Inducible Factor and Enhanced Reactive Oxygen Species Generation.

Fuchs K, Kuehn A, Mahling M, Guenthoer P, Hector A, Schwenck J, Hartl D, Laufer S, Kohlhofer U, Quintanilla-Martinez L, Reischl G, Röcken M, Pichler BJ, Kneilling M.

J Nucl Med. 2017 May;58(5):853-860. doi: 10.2967/jnumed.116.185934. Epub 2017 Feb 9.

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