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Items: 1 to 20 of 62

1.

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.

Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, Pomper MG, Dawson VL, Dawson TM, Ko HS.

Neuron. 2019 Jun 26. pii: S0896-6273(19)30488-X. doi: 10.1016/j.neuron.2019.05.035. [Epub ahead of print]

PMID:
31255487
2.

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.

Brahmachari S, Lee S, Kim S, Yuan C, Karuppagounder SS, Ge P, Shi R, Kim EJ, Liu A, Kim D, Quintin S, Jiang H, Kumar M, Yun SP, Kam TI, Mao X, Lee Y, Swing DA, Tessarollo L, Ko HS, Dawson VL, Dawson TM.

Brain. 2019 Jun 25. pii: awz172. doi: 10.1093/brain/awz172. [Epub ahead of print]

PMID:
31237944
3.

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.

Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste Marie EJ, Hondal RJ, Mukherjee S, Cave JW, Sagdullaev BT, Karuppagounder SS, Ratan RR.

Cell. 2019 May 16;177(5):1262-1279.e25. doi: 10.1016/j.cell.2019.03.032. Epub 2019 May 2.

PMID:
31056284
4.

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors.

Zille M, Kumar A, Kundu N, Bourassa MW, Wong VSC, Willis D, Karuppagounder SS, Ratan RR.

eNeuro. 2019 Feb 15;6(1). pii: ENEURO.0263-18.2019. doi: 10.1523/ENEURO.0263-18.2019. eCollection 2019 Jan-Feb.

5.

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons.

Xue Y, Zhan X, Sun S, Karuppagounder SS, Xia S, Dawson VL, Dawson TM, Laterra J, Zhang J, Ying M.

Stem Cells Transl Med. 2019 Feb;8(2):112-123. doi: 10.1002/sctm.18-0036. Epub 2018 Nov 1.

6.

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.

Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL.

Science. 2018 Nov 2;362(6414). pii: eaat8407. doi: 10.1126/science.aat8407.

7.

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.

Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29.

8.
9.

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.

Yun SP, Kam TI, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke VV, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS.

Nat Med. 2018 Jul;24(7):931-938. doi: 10.1038/s41591-018-0051-5. Epub 2018 Jun 11.

10.

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.

Xiong Y, Neifert S, Karuppagounder SS, Liu Q, Stankowski JN, Lee BD, Ko HS, Lee Y, Grima JC, Mao X, Jiang H, Kang SU, Swing DA, Iacovitti L, Tessarollo L, Dawson TM, Dawson VL.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1635-1640. doi: 10.1073/pnas.1712648115. Epub 2018 Jan 31.

11.

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.

Kim S, Yun SP, Lee S, Umanah GE, Bandaru VVR, Yin X, Rhee P, Karuppagounder SS, Kwon SH, Lee H, Mao X, Kim D, Pandey A, Lee G, Dawson VL, Dawson TM, Ko HS.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):798-803. doi: 10.1073/pnas.1700465115. Epub 2018 Jan 8.

12.

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.

Yun SP, Kim D, Kim S, Kim S, Karuppagounder SS, Kwon SH, Lee S, Kam TI, Lee S, Ham S, Park JH, Dawson VL, Dawson TM, Lee Y, Ko HS.

Mol Neurodegener. 2018 Jan 8;13(1):1. doi: 10.1186/s13024-017-0233-5.

13.

c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.

Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS.

J Parkinsons Dis. 2017;7(4):589-601. doi: 10.3233/JPD-171191.

14.

Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.

Xiong Y, Neifert S, Karuppagounder SS, Stankowski JN, Lee BD, Grima JC, Chen G, Ko HS, Lee Y, Swing D, Tessarollo L, Dawson TM, Dawson VL.

eNeuro. 2017 Mar 17;4(2). pii: ENEURO.0004-17.2017. doi: 10.1523/ENEURO.0004-17.2017. eCollection 2017 Mar-Apr.

15.

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR.

Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1.

16.

Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning.

Pignatelli M, Umanah GKE, Ribeiro SP, Chen R, Karuppagounder SS, Yau HJ, Eacker S, Dawson VL, Dawson TM, Bonci A.

Neuron. 2017 Jan 18;93(2):425-440. doi: 10.1016/j.neuron.2016.12.030.

17.

Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease.

Smirnova NA, Kaidery NA, Hushpulian DM, Rakhman II, Poloznikov AA, Tishkov VI, Karuppagounder SS, Gaisina IN, Pekcec A, Leyen KV, Kazakov SV, Yang L, Thomas B, Ratan RR, Gazaryan IG.

Aging Dis. 2016 Dec 1;7(6):745-762. doi: 10.14336/AD.2016.0505. eCollection 2016 Dec.

18.

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.

Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM.

Science. 2016 Sep 30;353(6307). pii: aah3374.

19.

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.

Brahmachari S, Ge P, Lee SH, Kim D, Karuppagounder SS, Kumar M, Mao X, Shin JH, Lee Y, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS.

J Clin Invest. 2016 Aug 1;126(8):2970-88. doi: 10.1172/JCI85456. Epub 2016 Jun 27.

20.

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.

Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, Ulja D, Karuppagounder SS, Holson EB, Ratan RR, Ninan I, Chao MV.

Elife. 2016 Jun 2;5. pii: e15092. doi: 10.7554/eLife.15092.

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