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Items: 1 to 20 of 35


Alternative polyadenylation factors link cell cycle to migration.

Mitra M, Johnson EL, Swamy VS, Nersesian LE, Corney DC, Robinson DG, Taylor DG, Ambrus AM, Jelinek D, Wang W, Batista SL, Coller HA.

Genome Biol. 2018 Oct 25;19(1):176. doi: 10.1186/s13059-018-1551-9.


Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.

Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR.

Cell. 2018 Sep 20;175(1):117-132.e21. doi: 10.1016/j.cell.2018.08.017. Epub 2018 Sep 6.


Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue.

Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA.

J Vis Exp. 2018 Jun 21;(136). doi: 10.3791/57760.


Lactate dehydrogenase activity drives hair follicle stem cell activation.

Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE.

Nat Cell Biol. 2017 Sep;19(9):1017-1026. doi: 10.1038/ncb3575. Epub 2017 Aug 14.


The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.

Castillo JJ, Jelinek D, Wei H, Gannon NP, Vaughan RA, Horwood LJ, Meaney FJ, Garcia-Smith R, Trujillo KA, Heidenreich RA, Meyre D, Orlando RA, LeBoeuf RC, Garver WS.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E183-E194. doi: 10.1152/ajpendo.00369.2016. Epub 2017 May 9.


Akt inhibitor MK-2206 in combination with bendamustine and rituximab in relapsed or refractory chronic lymphocytic leukemia: Results from the N1087 alliance study.

Larsen JT, Shanafelt TD, Leis JF, LaPlant B, Call T, Pettinger A, Hanson C, Erlichman C, Habermann TM, Reeder C, Nikcevich D, Bowen D, Conte M, Boysen J, Secreto C, Lesnick C, Tschumper R, Jelinek D, Kay NE, Ding W.

Am J Hematol. 2017 Aug;92(8):759-763. doi: 10.1002/ajh.24762. Epub 2017 Jun 1.


Differential Association of Niemann-Pick C1 Gene Polymorphisms with Maternal Prepregnancy Overweight and Gestational Diabetes.

Garver WS, de la Torre L, Brennan MC, Luo L, Jelinek D, Castillo JJ, Meyre D, Orlando RA, Heidenreich RA, Rayburn WF.

J Diabetes Obes. 2015;2(1). doi: 10.15436/2376-0494.15.007.


The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage is susceptible to increased weight gain when fed a high-fat diet: Confirmation of a gene-diet interaction.

Jelinek D, Castillo JJ, Heidenreich RA, Garver WS.

Gene. 2015 Aug 15;568(1):112-3. doi: 10.1016/j.gene.2015.05.025. Epub 2015 May 12. No abstract available.


The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight.

Jelinek D, Castillo JJ, Garver WS.

Gene. 2013 Sep 15;527(1):65-70. doi: 10.1016/j.gene.2013.05.080. Epub 2013 Jun 11.


A high-fat diet supplemented with fish oil improves metabolic features associated with type 2 diabetes.

Jelinek D, Castillo JJ, Arora SL, Richardson LM, Garver WS.

Nutrition. 2013 Sep;29(9):1159-65. doi: 10.1016/j.nut.2013.02.012. Epub 2013 Jun 4.


Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL.

Vardi A, Dagklis A, Scarfò L, Jelinek D, Newton D, Bennett F, Almeida J, Rodriguez-Caballero A, Allgood S, Lanasa M, Cortelezzi A, Orlandi E, Veronese S, Montillo M, Rawstron A, Shanafelt T, Orfao A, Stamatopoulos K, Ghia P.

Blood. 2013 May 30;121(22):4521-8. doi: 10.1182/blood-2012-12-471698. Epub 2013 Apr 17.


The genetics of childhood obesity and interaction with dietary macronutrients.

Garver WS, Newman SB, Gonzales-Pacheco DM, Castillo JJ, Jelinek D, Heidenreich RA, Orlando RA.

Genes Nutr. 2013 May;8(3):271-87. doi: 10.1007/s12263-013-0339-5. Epub 2013 Mar 8.


The Niemann-Pick C1 gene is downregulated in livers of C57BL/6J mice by dietary fatty acids, but not dietary cholesterol, through feedback inhibition of the SREBP pathway.

Jelinek D, Castillo JJ, Richardson LM, Luo L, Heidenreich RA, Garver WS.

J Nutr. 2012 Nov;142(11):1935-42. doi: 10.3945/jn.112.162818. Epub 2012 Sep 18.


The Niemann-Pick C1 gene interacts with a high-fat diet and modifying genes to promote weight gain.

Jelinek D, Heidenreich RA, Garver WS.

Am J Med Genet A. 2011 Sep;155A(9):2317-9. doi: 10.1002/ajmg.a.34135. Epub 2011 Aug 3. No abstract available.


Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia.

Shanafelt T, Zent C, Byrd J, Erlichman C, Laplant B, Ghosh A, Call T, Villalona-Calero M, Jelinek D, Bowen D, Laumann K, Wu W, Hanson C, Kay N.

Leuk Lymphoma. 2010 Dec;51(12):2222-9. doi: 10.3109/10428194.2010.524327. Epub 2010 Nov 5.


Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance.

Jelinek D, Millward V, Birdi A, Trouard TP, Heidenreich RA, Garver WS.

Hum Mol Genet. 2011 Jan 15;20(2):312-21. doi: 10.1093/hmg/ddq466. Epub 2010 Oct 29.


Decreased Npc1 gene dosage in mice is associated with weight gain.

Jelinek D, Heidenreich RA, Erickson RP, Garver WS.

Obesity (Silver Spring). 2010 Jul;18(7):1457-9. doi: 10.1038/oby.2009.415. Epub 2009 Nov 12.


Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments.

Jelinek D, Patrick SM, Kitt KN, Chan T, Francis GA, Garver WS.

J Cell Biochem. 2009 Dec 1;108(5):1102-16. doi: 10.1002/jcb.22339.


The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes.

Garver WS, Jelinek D, Meaney FJ, Flynn J, Pettit KM, Shepherd G, Heidenreich RA, Vockley CM, Castro G, Francis GA.

J Lipid Res. 2010 Feb;51(2):406-15. doi: 10.1194/jlr.P000331. Epub 2009 Sep 9.

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