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Differences in Clinical Course of Intraprocedural and Delayed Perforation Caused by Endoscopic Submucosal Dissection for Colorectal Neoplasms: A Retrospective Study.

Iwatsubo T, Takeuchi Y, Yamasaki Y, Nakagawa K, Arao M, Ohmori M, Iwagami H, Matsuno K, Inoue S, Nakahira H, Matsuura N, Shichijo S, Maekawa A, Kanesaka T, Yamamoto S, Higashino K, Uedo N, Ishihara R.

Dig Dis. 2018 Sep 18:1-10. doi: 10.1159/000492868. [Epub ahead of print]


LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.

Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9115-E9124. doi: 10.1073/pnas.1812196115. Epub 2018 Sep 12.


Endoscopic findings corresponding to multiple Lugol-voiding lesions in the esophageal background mucosa.

Matsuno K, Ishihara R, Nakagawa K, Ohmori M, Iwagami H, Inoue S, Iwatsubo T, Nakahira H, Matsuura N, Shichijyo S, Maekawa A, Takashi K, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Matsunaga T.

J Gastroenterol Hepatol. 2018 Aug 12. doi: 10.1111/jgh.14439. [Epub ahead of print]


A Novel Method to Estimate Long-Term Chronological Changes From Fragmented Observations in Disease Progression.

Ishida T, Tokuda K, Hisaka A, Honma M, Kijima S, Takatoku H, Iwatsubo T, Moritoyo T, Suzuki H; Alzheimer's Disease Neuroimaging Initiative.

Clin Pharmacol Ther. 2018 Jun 28. doi: 10.1002/cpt.1166. [Epub ahead of print]


Efficacy of vonoprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized phase II study.

Hamada K, Uedo N, Tonai Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Ishihara R, Okada H, Iishi H, Fukui K, Shimokawa T.

J Gastroenterol. 2018 Jun 25. doi: 10.1007/s00535-018-1487-6. [Epub ahead of print]


Traction-assisted colorectal endoscopic submucosal dissection by use of clip and line for a neoplasm involving colonic diverticulum.

Iwatsubo T, Uedo N, Yamasaki Y, Takeuchi Y, Ando Y.

VideoGIE. 2017 Nov 22;2(12):337-338. doi: 10.1016/j.vgie.2017.08.012. eCollection 2017 Dec. No abstract available.


Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease.

Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerrière A, Prasher V, Iwatsubo T, Strydom A.

Acta Neuropathol. 2018 May 16. doi: 10.1007/s00401-018-1866-3. [Epub ahead of print]


Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials.

Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H; Japanese Alzheimer's Disease Neuroimaging Initiative, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2018 Aug;14(8):1077-1087. doi: 10.1016/j.jalz.2018.03.009. Epub 2018 May 9.


Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.

Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T.

J Biol Chem. 2018 May 11;293(19):7267. doi: 10.1074/jbc.AAC118.003576. No abstract available.


Transoral endoscopic examination of head and neck region.

Hamada K, Ishihara R, Yamasaki Y, Akasaka T, Arao M, Iwatsubo T, Shichijo S, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Kawahara Y, Okada H.

Dig Endosc. 2018 Jul;30(4):516-521. doi: 10.1111/den.13071. Epub 2018 Apr 26.


Line-assisted complete closure for a large mucosal defect after colorectal endoscopic submucosal dissection decreased post-electrocoagulation syndrome.

Yamasaki Y, Takeuchi Y, Iwatsubo T, Kato M, Hamada K, Tonai Y, Matsuura N, Kanesaka T, Yamashina T, Arao M, Suzuki S, Shichijo S, Nakahira H, Akasaka T, Hanaoka N, Higashino K, Uedo N, Ishihara R, Okada H, Iishi H.

Dig Endosc. 2018 Sep;30(5):633-641. doi: 10.1111/den.13052. Epub 2018 Apr 29.


Impact of electrosurgical unit mode on post esophageal endoscopic submucosal dissection stricture in an in vivo porcine model.

Tonai Y, Ishihara R, Yamasaki Y, Arao M, Iwatsubo T, Kato M, Suzuki S, Hamada K, Shichijo S, Matsuura N, Kanesaka T, Nakahira H, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Uedo N, Tomita Y, Iishi H.

Endosc Int Open. 2018 Mar;6(3):E376-E381. doi: 10.1055/s-0043-122883. Epub 2018 Mar 7.


Extracellular α-synuclein levels are regulated by neuronal activity.

Yamada K, Iwatsubo T.

Mol Neurodegener. 2018 Feb 22;13(1):9. doi: 10.1186/s13024-018-0241-0.


Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.

Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T.

Hum Mol Genet. 2018 Apr 15;27(8):1353-1365. doi: 10.1093/hmg/ddy046.


Multiple convex demarcation line for prediction of benign depressed gastric lesions in magnifying narrow-band imaging.

Kanesaka T, Uedo N, Yao K, Ezoe Y, Doyama H, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Takeuchi Y, Arao M, Iwatsubo T, Iwagami H, Matsuno K, Muto M, Saito Y, Tomita Y.

Endosc Int Open. 2018 Feb;6(2):E145-E155. doi: 10.1055/s-0043-121267. Epub 2018 Feb 1.


Safety of cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis: a prospective exploratory study.

Hamada K, Takeuchi Y, Ishikawa H, Ezoe Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Tonai Y, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Higashino K, Uedo N, Ishihara R, Okada H, Iishi H.

Endoscopy. 2018 May;50(5):511-517. doi: 10.1055/s-0043-124765. Epub 2018 Jan 19.


Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.

Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T.

EMBO Mol Med. 2018 Mar;10(3). pii: e8184. doi: 10.15252/emmm.201708184.


Comparison of ENDO CUT mode and FORCED COAG mode for the formation of stricture after esophageal endoscopic submucosal dissection in an in vivo porcine model.

Arao M, Ishihara R, Tonai Y, Iwatsubo T, Shichijyo S, Matsuura N, Nakahira H, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Nakatsuka S.

Surg Endosc. 2018 Jun;32(6):2902-2906. doi: 10.1007/s00464-017-6000-4. Epub 2018 Jan 4.


The past, present, and future of disease-modifying therapies for Alzheimer's disease.

Suzuki K, Iwata A, Iwatsubo T.

Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(10):757-771. doi: 10.2183/pjab.93.048.


Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.

Fujimoto T, Kuwahara T, Eguchi T, Sakurai M, Komori T, Iwatsubo T.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):1708-1715. doi: 10.1016/j.bbrc.2017.12.024. Epub 2017 Dec 6.


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