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Items: 1 to 20 of 26


Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos.

Aksoy YA, Nguyen DT, Chow S, Chung RS, Guillemin GJ, Cole NJ, Hesselson D.

Commun Biol. 2019 May 23;2:198. doi: 10.1038/s42003-019-0444-0. eCollection 2019.


Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote.

Lau MT, Manion J, Littleboy JB, Oyston L, Khuong TM, Wang QP, Nguyen DT, Hesselson D, Seymour JE, Neely GG.

Nat Commun. 2019 Apr 30;10(1):1655. doi: 10.1038/s41467-019-09681-1.


Deletion distal to the PAX6 coding region reveals a novel basis for familial cosegregation of aniridia and diabetes mellitus.

Macdonald GC, Hesselson SE, Chan JY, Jenkins AB, Laybutt DR, Hesselson D, Campbell LV.

Diabetes Res Clin Pract. 2019 Feb;148:64-71. doi: 10.1016/j.diabres.2018.12.002. Epub 2018 Dec 17.


A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance.

Huttner IG, Wang LW, Santiago CF, Horvat C, Johnson R, Cheng D, von Frieling-Salewsky M, Hillcoat K, Bemand TJ, Trivedi G, Braet F, Hesselson D, Alford K, Hayward CS, Seidman JG, Seidman CE, Feneley MP, Linke WA, Fatkin D.

Circ Genom Precis Med. 2018 Aug;11(8):e002135. doi: 10.1161/CIRCGEN.118.002135.


Whole-Organism Chemical Screening Identifies Modulators of Pancreatic β-Cell Function.

Matsuda H, Mullapudi ST, Yang YHC, Masaki H, Hesselson D, Stainier DYR.

Diabetes. 2018 Nov;67(11):2268-2279. doi: 10.2337/db17-1223. Epub 2018 Aug 16.


Computer Animation Technology in Behavioral Sciences: A Sequential, Automatic, and High-Throughput Approach to Quantifying Personality in Zebrafish (Danio rerio).

Fangmeier ML, Noble DWA, O'Dea RE, Usui T, Lagisz M, Hesselson D, Nakagawa S.

Zebrafish. 2018 Apr;15(2):206-210. doi: 10.1089/zeb.2017.1532. Epub 2018 Jan 30.


The French press: a repeatable and high-throughput approach to exercising zebrafish (Danio rerio).

Usui T, Noble DWA, O'Dea RE, Fangmeier ML, Lagisz M, Hesselson D, Nakagawa S.

PeerJ. 2018 Jan 17;6:e4292. doi: 10.7717/peerj.4292. eCollection 2018.


Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs.

Hui SP, Sheng DZ, Sugimoto K, Gonzalez-Rajal A, Nakagawa S, Hesselson D, Kikuchi K.

Dev Cell. 2017 Dec 18;43(6):659-672.e5. doi: 10.1016/j.devcel.2017.11.010.


Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish.

Lagendijk AK, Gomez GA, Baek S, Hesselson D, Hughes WE, Paterson S, Conway DE, Belting HG, Affolter M, Smith KA, Schwartz MA, Yap AS, Hogan BM.

Nat Commun. 2017 Nov 10;8(1):1402. doi: 10.1038/s41467-017-01325-6.


Thyroid Hormone Coordinates Pancreatic Islet Maturation During the Zebrafish Larval-to-Juvenile Transition to Maintain Glucose Homeostasis.

Matsuda H, Mullapudi ST, Zhang Y, Hesselson D, Stainier DYR.

Diabetes. 2017 Oct;66(10):2623-2635. doi: 10.2337/db16-1476. Epub 2017 Jul 11.


Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy.

Zhang Y, Nguyen DT, Olzomer EM, Poon GP, Cole NJ, Puvanendran A, Phillips BR, Hesselson D.

Cell Chem Biol. 2017 Apr 20;24(4):471-480.e4. doi: 10.1016/j.chembiol.2017.03.005. Epub 2017 Mar 30.


Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis.

Jafari A, Qanie D, Andersen TL, Zhang Y, Chen L, Postert B, Parsons S, Ditzel N, Khosla S, Johansen HT, Kjærsgaard-Andersen P, Delaisse JM, Abdallah BM, Hesselson D, Solberg R, Kassem M.

Stem Cell Reports. 2017 Feb 14;8(2):373-386. doi: 10.1016/j.stemcr.2017.01.003. Epub 2017 Feb 2.


From bugs to beta cells.

Zhang Y, Hesselson D.

Elife. 2016 Dec 13;5. pii: e23065. doi: 10.7554/eLife.23065.


Genetic basis of hindlimb loss in a naturally occurring vertebrate model.

Don EK, de Jong-Curtain TA, Doggett K, Hall TE, Heng B, Badrock AP, Winnick C, Nicholson GA, Guillemin GJ, Currie PD, Hesselson D, Heath JK, Cole NJ.

Biol Open. 2016 Feb 18;5(3):359-66. doi: 10.1242/bio.016295.


The role of non-genetic inheritance in evolutionary rescue: epigenetic buffering, heritable bet hedging and epigenetic traps.

O'Dea RE, Noble DWA, Johnson SL, Hesselson D, Nakagawa S.

Environ Epigenet. 2016 Feb 15;2(1):dvv014. doi: 10.1093/eep/dvv014. eCollection 2016 Jan.


Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.

Malle EK, Zammit NW, Walters SN, Koay YC, Wu J, Tan BM, Villanueva JE, Brink R, Loudovaris T, Cantley J, McAlpine SR, Hesselson D, Grey ST.

J Exp Med. 2015 Jul 27;212(8):1239-54. doi: 10.1084/jem.20150218. Epub 2015 Jun 29.


Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.

Ye L, Robertson MA, Hesselson D, Stainier DY, Anderson RM.

Development. 2015 Apr 15;142(8):1407-17. doi: 10.1242/dev.117911.


Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis.

Anderson RM, Delous M, Bosch JA, Ye L, Robertson MA, Hesselson D, Stainier DY.

PLoS Genet. 2013;9(7):e1003650. doi: 10.1371/journal.pgen.1003650. Epub 2013 Jul 25.


Metabolic regulation of cellular plasticity in the pancreas.

Ninov N, Hesselson D, Gut P, Zhou A, Fidelin K, Stainier DY.

Curr Biol. 2013 Jul 8;23(13):1242-50. doi: 10.1016/j.cub.2013.05.037. Epub 2013 Jun 20.


Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.

Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY.

Nat Chem Biol. 2013 Feb;9(2):97-104. doi: 10.1038/nchembio.1136. Epub 2012 Dec 2.

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