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Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy.

Tapias V, Jainuddin S, Ahuja M, Stack C, Elipenahli C, Vignisse J, Gerges M, Starkova N, Xu H, Starkov AA, Bettendorff L, Hushpulian DM, Smirnova NA, Gazaryan IG, Kaidery NA, Wakade S, Calingasan NY, Thomas B, Gibson GE, Dumont M, Beal MF.

Hum Mol Genet. 2018 Aug 15;27(16):2874-2892. doi: 10.1093/hmg/ddy201.


Mild metabolic perturbations alter succinylation of mitochondrial proteins.

Chen H, Xu H, Potash S, Starkov A, Belousov VV, Bilan DS, Denton TT, Gibson GE.

J Neurosci Res. 2017 Nov;95(11):2244-2252. doi: 10.1002/jnr.24103. Epub 2017 Jun 20.


Mitochondria/metabolic reprogramming in the formation of neurons from peripheral cells: Cause or consequence and the implications to their utility.

Gibson GE, Thakkar A.

Neurochem Int. 2018 Jul;117:65-76. doi: 10.1016/j.neuint.2017.06.007. Epub 2017 Jun 13. Review.


Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View.

Gibson GE, Thakkar A.

Neurochem Res. 2017 Jun;42(6):1636-1648. doi: 10.1007/s11064-017-2182-3. Epub 2017 Feb 8. Review.


Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington's Disease Patients.

Naseri NN, Bonica J, Xu H, Park LC, Arjomand J, Chen Z, Gibson GE.

PLoS One. 2016 Sep 9;11(9):e0160384. doi: 10.1371/journal.pone.0160384. eCollection 2016.


Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE.

J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836.


Vitamin B1 (thiamine) and dementia.

Gibson GE, Hirsch JA, Fonzetti P, Jordan BD, Cirio RT, Elder J.

Ann N Y Acad Sci. 2016 Mar;1367(1):21-30. doi: 10.1111/nyas.13031. Epub 2016 Mar 11. Review.


Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease.

Banerjee K, Munshi S, Xu H, Frank DE, Chen HL, Chu CT, Yang J, Cho S, Kagan VE, Denton TT, Tyurina YY, Jiang JF, Gibson GE.

Neurochem Int. 2016 Jun;96:32-45. doi: 10.1016/j.neuint.2016.02.011. Epub 2016 Feb 23.


Abnormal Glucose Metabolism in Alzheimer's Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches.

Banerjee K, Munshi S, Frank DE, Gibson GE.

Neurochem Res. 2015 Dec;40(12):2557-69. doi: 10.1007/s11064-015-1631-0. Epub 2015 Jun 16. Review.


Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model.

Naseri NN, Xu H, Bonica J, Vonsattel JP, Cortes EP, Park LC, Arjomand J, Gibson GE.

J Neuropathol Exp Neurol. 2015 Jun;74(6):527-37. doi: 10.1097/NEN.0000000000000197.


Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects.

Zhao W, Wang J, Varghese M, Ho L, Mazzola P, Haroutunian V, Katsel PL, Gibson GE, Levine S, Dubner L, Pasinetti GM.

Neuropsychiatr Dis Treat. 2015 Mar 5;11:565-74. doi: 10.2147/NDT.S74898. eCollection 2015.


Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.

Gibson GE, Xu H, Chen HL, Chen W, Denton TT, Zhang S.

J Neurochem. 2015 Jul;134(1):86-96. doi: 10.1111/jnc.13096. Epub 2015 Apr 8.


The RNA-binding protein HuR is essential for the B cell antibody response.

Diaz-Muñoz MD, Bell SE, Fairfax K, Monzon-Casanova E, Cunningham AF, Gonzalez-Porta M, Andrews SR, Bunik VI, Zarnack K, Curk T, Heggermont WA, Heymans S, Gibson GE, Kontoyiannis DL, Ule J, Turner M.

Nat Immunol. 2015 Apr;16(4):415-25. doi: 10.1038/ni.3115. Epub 2015 Feb 23.


Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry.

Huang HM, Chen HL, Gibson GE.

Metab Brain Dis. 2014 Dec;29(4):1083-93. doi: 10.1007/s11011-014-9541-4. Epub 2014 Apr 22.


The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.

Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C.

FASEB J. 2013 Jun;27(6):2392-406. doi: 10.1096/fj.12-220202. Epub 2013 Mar 8.


Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes.

Gibson GE, Hirsch JA, Cirio RT, Jordan BD, Fonzetti P, Elder J.

Mol Cell Neurosci. 2013 Jul;55:17-25. doi: 10.1016/j.mcn.2012.09.001. Epub 2012 Sep 13. Review.


Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation.

Gibson GE, Chen HL, Xu H, Qiu L, Xu Z, Denton TT, Shi Q.

Neurobiol Aging. 2012 Jun;33(6):1121.e13-24. doi: 10.1016/j.neurobiolaging.2011.11.003. Epub 2011 Dec 14.


Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a.

Shi Q, Gibson GE.

J Neurochem. 2011 Aug;118(3):440-8. doi: 10.1111/j.1471-4159.2011.07333.x. Epub 2011 Jun 24.


Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex.

Shi Q, Xu H, Yu H, Zhang N, Ye Y, Estevez AG, Deng H, Gibson GE.

J Biol Chem. 2011 May 20;286(20):17640-8. doi: 10.1074/jbc.M110.203018. Epub 2011 Mar 25.


Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity.

Nilsen LH, Shi Q, Gibson GE, Sonnewald U.

J Neurosci Res. 2011 Dec;89(12):1997-2007. doi: 10.1002/jnr.22606. Epub 2011 Mar 3.

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