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Items: 1 to 20 of 131

1.

Quantitative Laser Diffraction for Quantification of Protein Aggregates: Comparison With Resonant Mass Measurement, Nanoparticle Tracking Analysis, Flow Imaging, and Light Obscuration.

Yoneda S, Niederleitner B, Wiggenhorn M, Koga H, Totoki S, Krayukhina E, Friess W, Uchiyama S.

J Pharm Sci. 2018 Sep 17. pii: S0022-3549(18)30531-8. doi: 10.1016/j.xphs.2018.09.004. [Epub ahead of print]

2.

Crystallizing amino acids as bulking agents in freeze-drying.

Horn J, Tolardo E, Fissore D, Friess W.

Eur J Pharm Biopharm. 2018 Nov;132:70-82. doi: 10.1016/j.ejpb.2018.09.004. Epub 2018 Sep 7.

PMID:
30201570
3.

A New Approach to Study the Physical Stability of Monoclonal Antibody Formulations-Dilution From a Denaturant.

Svilenov H, Gentiluomo L, Friess W, Roessner D, Winter G.

J Pharm Sci. 2018 Dec;107(12):3007-3013. doi: 10.1016/j.xphs.2018.08.004. Epub 2018 Aug 16.

PMID:
30121313
4.

Zn2+-triggered self-assembly of Gonadorelin [6-D-Phe] to produce nanostructures and fibrils.

Yordanova Y, Vanderlinden W, Stoll R, Rüdiger D, Tosstorff A, Zaremba W, Winter G, Zahler S, Friess W.

Sci Rep. 2018 Jul 26;8(1):11280. doi: 10.1038/s41598-018-29529-w.

5.

Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products.

Haeuser C, Goldbach P, Huwyler J, Friess W, Allmendinger A.

J Pharm Sci. 2018 Nov;107(11):2810-2822. doi: 10.1016/j.xphs.2018.06.025. Epub 2018 Jul 10.

PMID:
30005985
6.

Does controlled nucleation impact the properties and stability of lyophilized monoclonal antibody formulations?

Vollrath I, Friess W, Freitag A, Hawe A, Winter G.

Eur J Pharm Biopharm. 2018 Aug;129:134-144. doi: 10.1016/j.ejpb.2018.05.025. Epub 2018 May 22.

PMID:
29800618
7.

The missing piece in the puzzle: Prediction of aggregation via the protein-protein interaction parameter A2.

Koepf E, Schroeder R, Brezesinski G, Friess W.

Eur J Pharm Biopharm. 2018 Jul;128:200-209. doi: 10.1016/j.ejpb.2018.04.024. Epub 2018 Apr 30.

PMID:
29723667
8.

Lipid-coated mannitol core microparticles for sustained release of protein.

Wang B, Friess W.

Eur J Pharm Biopharm. 2018 Jul;128:91-97. doi: 10.1016/j.ejpb.2018.04.022. Epub 2018 Apr 20.

PMID:
29684533
9.

Impact of fast and conservative freeze-drying on product quality of protein-mannitol-sucrose-glycerol lyophilizates.

Horn J, Schanda J, Friess W.

Eur J Pharm Biopharm. 2018 Jun;127:342-354. doi: 10.1016/j.ejpb.2018.03.003. Epub 2018 Mar 6.

PMID:
29522899
10.

Impact of formulation pH on physicochemical protein characteristics at the liquid-air interface.

Koepf E, Richert M, Braunschweig B, Schroeder R, Brezesinski G, Friess W.

Int J Pharm. 2018 Apr 25;541(1-2):234-245. doi: 10.1016/j.ijpharm.2018.02.009. Epub 2018 Feb 24.

PMID:
29486287
11.

Detection of Collapse and Crystallization of Saccharide, Protein, and Mannitol Formulations by Optical Fibers in Lyophilization.

Horn J, Friess W.

Front Chem. 2018 Jan 26;6:4. doi: 10.3389/fchem.2018.00004. eCollection 2018.

12.

Notorious but not understood: How liquid-air interfacial stress triggers protein aggregation.

Koepf E, Eisele S, Schroeder R, Brezesinski G, Friess W.

Int J Pharm. 2018 Feb 15;537(1-2):202-212. doi: 10.1016/j.ijpharm.2017.12.043. Epub 2017 Dec 26.

PMID:
29288093
13.

Formation of mannitol core microparticles for sustained release with lipid coating in a mini fluid bed system.

Wang B, Friess W.

Eur J Pharm Biopharm. 2017 Nov;120:126-132. doi: 10.1016/j.ejpb.2017.09.003. Epub 2017 Sep 8.

PMID:
28893692
14.

Spray drying of silica microparticles for sustained release application with a new sol-gel precursor.

Wang B, Friess W.

Int J Pharm. 2017 Oct 30;532(1):281-288. doi: 10.1016/j.ijpharm.2017.09.016. Epub 2017 Sep 8.

PMID:
28890172
15.

The film tells the story: Physical-chemical characteristics of IgG at the liquid-air interface.

Koepf E, Schroeder R, Brezesinski G, Friess W.

Eur J Pharm Biopharm. 2017 Oct;119:396-407. doi: 10.1016/j.ejpb.2017.07.006. Epub 2017 Jul 22.

PMID:
28743595
16.

Development of a Perfusion Platform for Dynamic Cultivation of in vitro Skin Models.

Strüver K, Friess W, Hedtrich S.

Skin Pharmacol Physiol. 2017;30(4):180-189. doi: 10.1159/000476071. Epub 2017 Jun 27.

17.

Lyophilization Cycle Design for Dual Chamber Cartridges and a Method for Online Process Control: The "DCC LyoMate" Procedure.

Korpus C, Friess W.

J Pharm Sci. 2017 Aug;106(8):2077-2087. doi: 10.1016/j.xphs.2017.04.069. Epub 2017 May 4.

PMID:
28479354
18.

Trends on Analytical Characterization of Polysorbates and Their Degradation Products in Biopharmaceutical Formulations.

Martos A, Koch W, Jiskoot W, Wuchner K, Winter G, Friess W, Hawe A.

J Pharm Sci. 2017 Jul;106(7):1722-1735. doi: 10.1016/j.xphs.2017.03.001. Epub 2017 Mar 14. Review.

PMID:
28302541
19.

Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying.

Vollrath I, Pauli V, Friess W, Freitag A, Hawe A, Winter G.

J Pharm Sci. 2017 May;106(5):1249-1257. doi: 10.1016/j.xphs.2016.12.030. Epub 2017 Jan 4.

PMID:
28063826
20.

Evaluation of Different Holder Devices for Freeze-Drying in Dual-Chamber Cartridges With a Focus on Energy Transfer.

Korpus C, Friess W.

J Pharm Sci. 2017 Apr;106(4):1092-1101. doi: 10.1016/j.xphs.2016.12.016. Epub 2016 Dec 28.

PMID:
28039019

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