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Items: 11


The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.

Boscardin E, Alijevic O, Hummler E, Frateschi S, Kellenberger S.

Br J Pharmacol. 2016 Sep;173(18):2671-701. doi: 10.1111/bph.13533. Epub 2016 Aug 10. Review.


Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.

Canonica J, Sergi C, Maillard M, Klusonova P, Odermatt A, Koesters R, Loffing-Cueni D, Loffing J, Rossier B, Frateschi S, Hummler E.

Pflugers Arch. 2016 May;468(5):895-908. doi: 10.1007/s00424-015-1785-2. Epub 2016 Jan 14.


Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit.

Perrier R, Boscardin E, Malsure S, Sergi C, Maillard MP, Loffing J, Loffing-Cueni D, Sørensen MV, Koesters R, Rossier BC, Frateschi S, Hummler E.

J Am Soc Nephrol. 2016 Aug;27(8):2309-18. doi: 10.1681/ASN.2015020154. Epub 2015 Dec 23.


Regulation of blood pressure and renal function by NCC and ENaC: lessons from genetically engineered mice.

Verouti SN, Boscardin E, Hummler E, Frateschi S.

Curr Opin Pharmacol. 2015 Apr;21:60-72. doi: 10.1016/j.coph.2014.12.012. Epub 2015 Jan 20. Review.


The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.

Crisante G, Battista L, Iwaszkiewicz J, Nesca V, Mérillat AM, Sergi C, Zoete V, Frateschi S, Hummler E.

FASEB J. 2014 Nov;28(11):4792-805. doi: 10.1096/fj.14-253781. Epub 2014 Aug 19.


The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.

Hummler E, Dousse A, Rieder A, Stehle JC, Rubera I, Osterheld MC, Beermann F, Frateschi S, Charles RP.

PLoS One. 2013;8(2):e55796. doi: 10.1371/journal.pone.0055796. Epub 2013 Feb 6.


Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity.

Frateschi S, Keppner A, Malsure S, Iwaszkiewicz J, Sergi C, Merillat AM, Fowler-Jaeger N, Randrianarison N, Planès C, Hummler E.

Am J Pathol. 2012 Aug;181(2):605-15. doi: 10.1016/j.ajpath.2012.05.007. Epub 2012 Jun 13.


PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.

Frateschi S, Camerer E, Crisante G, Rieser S, Membrez M, Charles RP, Beermann F, Stehle JC, Breiden B, Sandhoff K, Rotman S, Haftek M, Wilson A, Ryser S, Steinhoff M, Coughlin SR, Hummler E.

Nat Commun. 2011 Jan 18;2:161.


ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.

Planès C, Randrianarison NH, Charles RP, Frateschi S, Cluzeaud F, Vuagniaux G, Soler P, Clerici C, Rossier BC, Hummler E.

EMBO Mol Med. 2010 Jan;2(1):26-37. doi: 10.1002/emmm.200900050.


Comparison of two molecular methods used for subtyping of Legionella pneumophila 1 strains isolated from a hospital water supply.

Casini B, Valentini P, Baggiani A, Torracca F, Lorenzini C, Frateschi S, Matteoli B, Privitera G.

Water Sci Technol. 2008;58(3):683-8. doi: 10.2166/wst.2008.434.


Molecular epidemiology of Legionella pneumophila serogroup 1 isolates following long-term chlorine dioxide treatment in a university hospital water system.

Casini B, Valentini P, Baggiani A, Torracca F, Frateschi S, Nelli LC, Privitera G.

J Hosp Infect. 2008 Jun;69(2):141-7. doi: 10.1016/j.jhin.2008.03.003. Epub 2008 Apr 24.


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